Abstract
The aims of this study were to examine the effects of systemic injection of diazepam on memory as measured by the intrasession evolution of alternation response rates in both sequential and delayed procedures. We showed that diazepam injection produced delay-dependent impairments in both sequential and delayed alternation protocols. However, the delayed alternation deficit produced by diazepam was totally alleviated by an intramaze context change occurring only before the retention trial. The memory-enhancing effect of the intramaze context change in experimental mice demonstrated that diazepam injection induced, during the usual testing (no-context change) conditions, a time-dependent retrieval memory deficit.
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This research was supported by the CNRS, URA 339.
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Borde, N., Krazem, A., Jaffard, A. et al. Memory deficits following diazepam administration in mice: Evidence for a time-dependent retrieval impairment. Psychobiology 25, 202–209 (1997). https://doi.org/10.3758/BF03331928
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DOI: https://doi.org/10.3758/BF03331928