Abstract
Ditran, atropine sulfate, d-amphetamine, chlorpromazine, or isotonic saline were administered intraperitoneally to BDF1 mice prior to measurement of exploratory activity. D-amphetamine and chlorpromazine decreased exploration, whereas the anticholinergic compounds Ditran and atropine sulfate increased exploratory activity.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
ABOOD, L. G., OSTFELD, A., & BIEL, J. H. Structure-activity relationships of 3-piperidyl benzilates with psychotogenic properties. Archives Internationales de Pharmacodynamic, 1959, 120, 186–200.
BOISSIER, J. R., & SIMON, P. Dissociation de deux composantes le comportment d’investigation de la souris. Archives Internationales de Pharmocodynamie, 1964, 47, 372–387.
CARLTON, P. L. Cholinergic mechanisms in the control of behavior by the brain. Psychological Review, 1963, 70, 19–39.
COHEN, M. A feeding method for evaluating anticholinergic psychomimetic drugs. Archives Internationales de Pharmacodynamic, 1966, 161, 120–125.
IRWIN, S. The actions of drugs on psychomotor activity. Review of Canadian Biology, 1961, 20, 239–250.
LIPMAN, V. C., SHURRAGER, P. S., & ABOOD, L. G. Effect of anticholinergic psychotomimetics on motor activity and body temporature. Archives Internationales de Pharmacodynamic, 1963, 146, 174–191.
ROSENTHAL, R. Experimenter outcome-orientation and the results of the psychological experiment. Psychological Bulletin, 1964, 61, 405–412.
TRIPOD, J., BEIN, J., & MEIER, R. Characterization of central effects of Serpasil (reserpine, a new alkaloid of Rawolfia serpentina B.) and their antagonistic reactions. Archives Internationales Pharmacodynamic, 1954, 96, 406–425.
Author information
Authors and Affiliations
Additional information
Supported by IIT Research Institute, Chicago, Illinois. Ditran was generously supplied by Lakeside Laboratories, Milwaukee, Wis. The advice of Dr. M. Cohen and Dr. R. Sroges is gratefully acknowledged.
Rights and permissions
About this article
Cite this article
Wakeley, H.G., O’Sullivan, D. Drug effects on mouse exploratory behavior. Psychon Sci 16, 27–28 (1969). https://doi.org/10.3758/BF03331896
Published:
Issue Date:
DOI: https://doi.org/10.3758/BF03331896