Abstract
Mice treated with nicotine sulfate (1.0 mg/kg, i.p.) prior to training for a passive avoidance response showed antagonism toward the amnesic effect produced by a post-training electroconvulsive shock; this effect was particularly apparent when drug treatment was given 45 to 60 min prior to training. A reversal of the predicted effect of ECS upon brain serotonin level by nicotine suggested a possible corrolary of the drug-induced facilitation of memory consolidation.
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1. This study was supported in part by grants from the Council for Tobacco Research-USA and the National Institutes of Health (MH-13191-01).
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Essman, W.B., Steinberg, M.L. & Golod, M.I. Alterations in the behavioral and biochemical effects of electroconvulsive shock with nicotine. Psychon Sci 12, 107–108 (1968). https://doi.org/10.3758/BF03331220
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DOI: https://doi.org/10.3758/BF03331220