Abstract
An experiment was conducted with rats to evaluate the effect of various low frequencies of brain stimulation on kindling behavior induced by 60-Hz sine-wave stimulation. The effective threshold intensity (ETI) to elicit altered behavior was determined on four separate occasions, with 5 days of daily trials between determinations. On each day, experimental rats were stimulated with current of a specific frequency on the first and third trials and with 60-Hz current on the second trial. There were four experimental groups, one each for 1-, .1-, .01-, and .001-Hz stimulation. A fifth group received no stimulation on Trials 1 and 3 and 60-Hz current on Trial 2. Suppression of altered behavior induced by the 60-Hz stimulation trial was present for all ETI determinations with the four experimental groups; the mean threshold increased on each successive determination. Suppression was greatest for the .1, .01, and .001 groups. Grossly, it appears that the interference effect gradually increases with decreasing frequency.
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Gaito, J. Research in progress, 1982.
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Gaito, J. The effect of ultra low-frequency brain stimulation on the kindling effect in rats. Bull. Psychon. Soc. 19, 303–306 (1982). https://doi.org/10.3758/BF03330265
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DOI: https://doi.org/10.3758/BF03330265