Abstract
The use of 1- or 3-Hz brain stimulation has been effective in eliminating or preventing kindling behavior produced by 60-Hz stimulation. In this paper, statistical data are presented on the effects of duration of stimulation on suppressing this kindling behavior. For experimental rats, each daily experiment involved the sandwiching of the kindling-producing agent (60-Hz sine wave stimulation) between trials of the suppression-producing agent (1-Hz or 3-Hz sine waves) (i.e., a sequence of 1-60-1 or 3-60-3). The durations used were 0 (control), 5, 15, 30, 60, 120, 180, 300, and 600 sec. In general, the degree of suppression increased with increasing duration of stimulation. Recovery from suppression following 15 or 16 days of nonstimulation decreased with increasing durations. Complete, or near complete, recovery resulted with durations of 60 sec or less; however, there was some recovery in all groups.
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The author thanks Judith Emslie for calculating the means and standard deviations reported in this paper.
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Gaito, J. The suppression of kindling with low-frequency brain stimulation: Statistical data with duration variable. Bull. Psychon. Soc. 23, 332–334 (1985). https://doi.org/10.3758/BF03330174
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DOI: https://doi.org/10.3758/BF03330174