Bulletin of the Psychonomic Society

, Volume 26, Issue 6, pp 563–564 | Cite as

Fluprazine hydrochloride decreases play behavior but not social grooming in juvenile male rats

  • Kerry J. Selseth
  • Ernest D. Kemble


Treatment with 8 mg/kg fluprazine hydrochloride strongly inhibited the play behavior of juvenile male rats but had no effect on social grooming. The results indicate that fluprazine affects play behavior as well as conspecific and predatory attack, male copulation, and maternal behavior. These drug actions may result from a rather generalized disruption in higher order stimulus processing or a drug-induced potentiation of fearfulness.


  1. Bean, N. J. (1982). Modulation of agonistic behavior by the dual olfactory system in male mice. Physiology & Behavior, 29, 433–437.CrossRefGoogle Scholar
  2. Blanchard, D. C., Takushi, R., Blanchard, R. J., Flannelly, K. J., & Kemble, E. D. (1985). Fluprazine hydrochloride does not decrease defensive behaviors of wild and septal syndrome rats. Physiology & Behavior, 35, 349–353.CrossRefGoogle Scholar
  3. Bradford, L. D., Olivier, B., van Dalen, D., & Schipper, J. (1984). Serenics: The pharmacology of fluprazine and DU 28412. In K. A. Miczek, M. R. Kruk, & B. Olivier (Eds.), Ethnopharmacological aggression research (pp. 191–207). New York: Liss.Google Scholar
  4. Bronson, F. H. (1974). Pheromonal influences on reproductive activities in rodents. In M. C. Birch (Ed.), Pheromones (pp. 344–365). New York: American Elsevier.Google Scholar
  5. Fagen, R. (1981). Animal play behavior. New York: Oxford University Press.Google Scholar
  6. Flannelly, K. J., Lim, H., Diamond, M., Blanchard, D. C., & Blanchard, R. J. (1985). Fluprazine hydrochloride decreases copulation in male rats. Pharmacology, Biochemistry & Behavior, 22, 1–4.CrossRefGoogle Scholar
  7. Flannelly, K. J., Muraoka, M. Y., Blanchard, D. C., & Blanchard, R. J. (1985). Specific anti-aggressive effects of fluprazine hydrochloride. Psychopharmacology, 87, 86–89.PubMedCrossRefGoogle Scholar
  8. Kemble, E. D., & Schultz, L. A. (in press). Effects of fluprazine hydrochloride on maternal behavior in mice. Behavioural Processes. Google Scholar
  9. Kemble, E. D., Thornton, A. E., & Schultz, L. A. (1987). Some fear-potentiating effects of fluprazine hydrochloride in mice. Aggressive Behavior, 13, 269–280.CrossRefGoogle Scholar
  10. Meany, M. J., & Stewart, J. (1981). A descriptive study of social development in the rat. (Rattus norvegicus). Animal Behavior, 29, 34–45.CrossRefGoogle Scholar
  11. Murphy, M. R., & Schneider, G. E. (1970). Olfactory bulb removal eliminates mating behavior in the male golden hamster. Science, 167, 302–304.PubMedCrossRefGoogle Scholar
  12. Olivier, B., Mos, J., van der Poel, A. M., Krijzer, F. N. C., & Kruk, M. R. (1984). Effects of a new psychoactive drug (DU27716) on different models of rat agonistic behaviour and EEG. In K. J. Flannelly, R. J. Blanchard, & D. C. Blanchard (Eds.), Biological perspectives on aggression (pp. 261–279). New York: Liss.Google Scholar
  13. Panksepp, J., & Beatty, W. W. (1980). Social deprivation and play in rats. Behavioral & Neural Biology, 30, 197–206.CrossRefGoogle Scholar
  14. Pellis, S. M., & Pellis, V. C. (1987). Play-fighting differs from serious fighting in both target of attack and tactics of fighting in the laboratory rat (Rattus norvegicus). Aggressive Behavior, 13, 227–242.CrossRefGoogle Scholar
  15. Racine, M. A., Flannelly, K. J., & Blanchard, D. C. (1984). Anti-aggressive effects of DU 27716 on attack and defensive behaviors in male mice. In K. J. Flannelly, R. J. Blanchard, & D. C. Blanchard (Eds.), Biological perspectives on aggression (pp. 281–294). New York: Liss.Google Scholar
  16. Schultz, L. A., & Kemble, E. D. (1986). Prey-dependent effects of fluprazine hydrochloride on predatory aggression in northern grasshopper mice (Onychomys leucogaster) and rats (Rattus norvegicus). Aggressive Behavior, 12, 267–275.CrossRefGoogle Scholar
  17. Thor, D. H., & Holloway, W. R. (1982). Anosmia and play fighting behavior in prepubescent male and female rats. Physiology & Behavior, 29, 281–285.CrossRefGoogle Scholar

Copyright information

© Psychonomic Society, Inc. 1988

Authors and Affiliations

  • Kerry J. Selseth
    • 1
  • Ernest D. Kemble
    • 1
  1. 1.Division of Social SciencesUniversity of Minnesota—MorrisMorris

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