Abstract
Rats with electrodes in the lateral hypothalamus were trained in a two-lever preference apparatus following 23 h of water deprivation to press for hypothalamic stimulation or water. The hypothalamic stimulation induced water intake, indicating that the electrodes were in the “drinking system.” When the current intensity was optimal for self-stimulation, the animals pressed the lever that delivered hypothalamic stimulation and ignored the lever that delivered water. After reducing the current intensity, they divided their presses between the two levers. The administration of amphetamine increased lever pressing for hypothalamic stimulation and reduced lever pressing for water. The administration of phenobarbital increased lever pressing for water but reduced only slightly lever pressing for hypothalamic stimulation.
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Research was supported by grants from the MRC and the NRC of Canada. The technical assistance of Mrs. Mary Dinning and the suggestions of Mr. A. G. Phillips during the preparation of the manuscript are gratefully acknowledged.
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Mogenson, G.J. Effects of drugs on the preference between electrical stimulation of the lateral hypothalamus and water. Psychon Sci 17, 13–14 (1969). https://doi.org/10.3758/BF03329141
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DOI: https://doi.org/10.3758/BF03329141