Abstract
Adult female rats were subjected to bilateral lesions of varying extent in the ventromedial nuclei of the hypothalamus. On reaching asymptote, Ss were given subcutaneous injections of protamine zinc insulin, daily, for 10 days. Obesity asymptote attained by brain damage was positively correlated with judged extent of lesions, while insulin-induced superobesity was negatively correlated with hypothalamic obesity asymptote. No relationship was found between the time taken to reach hypothalamic obesity asymptote and the asymptotic weight.
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ANAND, B. K., CHHINA, G. S., & SINGH, B. Effect of glucose on the activity of the hypothalamic “feeding centers.” Science, 1962, 138, 597–598.
BROBECK, J. R. Mechanisms of the development of obesity in animals with hypothalamic lesions. Physiological Review, 1946, 26, 541–559.
BROBECK, J. R. Regulation of feeding and drinking. In J. Field (Ed.), Handbook of physiology. Sec. 1, Vol. II. Baltimore: Waverley Press, 1960. Pp. 1197–1206.
HOEBEL, B. G., & TEITELBAUM, P. Weight regulation in normal and hypothalamic hyperphagic rats. Journal of Comparative & Physiological Psychology, 1966, 61, 189–193.
MAYER, J. Regulation of energy intake and the body weight: The glucostatic theory and the lipostatic hypothesis. Annals of the New York Academy of Science, 1955, 63, 15–43.
MORGANE, P. J. Medial forebrain bundle and “feeding centers” of the hypothalamus. Journal of Comparative Neurology, 1961, 117, 1–25.
TEITELBAUM, P. Disturbances in eating and drinking behavior after hypothalamic lesions. In M. E. Jones (Ed.), Nebraska Symposium on Motivation: 1961. Lincoln: University of Nebraska Press, 1961. Pp. 29–69.
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This study was supported by Small Grant M15770-1 awarded to Gordon Spies by the National Institute of Mental Health, United States Public Health Service.
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Spies, G., Turner, W.M. Insulin hypoglycemia and hypothalamic hyperphagia. Psychon Sci 20, 311–312 (1970). https://doi.org/10.3758/BF03329084
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DOI: https://doi.org/10.3758/BF03329084