Abstract
Electroconvulsive shock (ECS) was administered to mice 10 sec, 120 sec, and 3 h after training in a passive avoidance task. Subgroups were retested at 24 h, 48 h, 72 h, 1 week, and 4 weeks. A temporal gradient of retrograde amnesia was produced, with ECS still being effective even when given 3 h after training. The gradient was maintained over all retest times. No evidence of recovery could be detected.
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This research was supported by a USPHS grant MH 05319, and a Special Fellowship from the National Institute of Neurological Diseases and Stroke, 1F10 NS0223201. The authors wish to thank Mr. David Barth for his technical assistance.
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Geller, A., Jarvik, M.E. & Robustelli, F. Permanence of a long temporal gradient of retrograde amnesia induced by electroconvulsive shock. Psychon Sci 19, 257–259 (1970). https://doi.org/10.3758/BF03328805
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DOI: https://doi.org/10.3758/BF03328805