Abstract
Rats responding under a non-discriminated avoidance schedule having a 20 sec. shock-shock and shock-response interval were dosed with 3.0 mg/kg chlorpromazine. The resultant depression of response rate was antagonized with various doses of methamphetamine thus developing a dose-effect antagonistic relationship. These data did not reflect any marked increase in drug action sensitivity over that obtained from discriminated avoidance or food reinforced techniques.
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1. This work was done under Contract No. DA18-108-AMC-108(A) from U. S. Army Research Laboratories, Edgewood Arsenal, Edge-wood, Maryland to PMC Corporation, Princeton, New Jersey with Abbott Laboratories as subcontractor.
2. In conducting the research reported herein, the investigators adhered to “Principles of Laboratory Animal Care” as established by the National Society for Medical Research.
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Brown, H. Chlorpromazine-methamphetamine antagonism in a non-discriminated avoidance schedule. Psychon Sci 6, 95–96 (1966). https://doi.org/10.3758/BF03327974
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DOI: https://doi.org/10.3758/BF03327974