Abstract
The influence of age at infection on the nature of the behavioral effects of herpes simplex type 1 encephalitis in mice was examined. Weanling and adult mice were initially immunized with a footpad (FP) inoculation of virus, followed 2 weeks later by an intracerebral (IC) inoculation. Subsequent open-field testing 2 weeks later revealed that weanling mice were hypoactive and showed a reduced proportion of center-field entries. In contrast, adult mice were hyperactive. No significant effects on Y-maze alternation or activity were observed. These results indicate that the qualitative nature of the effects of herpes encephalitis on behavior depends upon characteristics of the host.
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McFarland, D.J., Sikora, E. & Hotchin, J. Age at infection as a determinant of the behavioral effects of herpes encephalitis in mice. Psychobiology 9, 87–89 (1981). https://doi.org/10.3758/BF03326963
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DOI: https://doi.org/10.3758/BF03326963