Abstract
Rats drinking freely 1.0% sodium saccharin solution and eating a reduced food ration, whether mixed (5.0%) or not with saccharin, lost body weight and died. Death depended neither on the absolute saccharin amount per gram of body weight nor on the nonconcurrence of saccharin and food ingestion, but instead, depended on the saccharin and the intermeal interval. Saccharin animals died on the 20 g/48 h and the 10 g/24 h food regimens and did not die on the 5 g/12 h. Rats did not die on any schedule if they ate food and drank water only. The behavioral consequences of saccharin and its potential harm to all animals, and to those on a reduced diet in particular, were emphasized.
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Arnold, D. L., Moodie, C. A., Grice, H. C., Charbonneau, S. M., Stavric, B., & Munro, I. C. Long term toxicity of orthotoluenesulfonamide and saccharin in the rat. Paper presented at the Toxicology Forum, The Eppley Institute for Research in Cancer, May 10, 1977.
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Thanks are extended to Ronald Levine and Judith Dunetz, who assisted in collecting data for Experiments 1 and 2, respectively.
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Strouthes, A. Mortality and the concurrent ingestion of food and saccharin in rats. Psychobiology 6, 89–92 (1978). https://doi.org/10.3758/BF03326699
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DOI: https://doi.org/10.3758/BF03326699