Abstract
Sucrose aversions were induced by lithium chloride toxicosis in 9-week-old male and female mice of the C57BL/6J and DBA/2J strains. Under conditions of ad-lib access to fluids which required a long interval between the sucrose and toxicosis, the conditioned aversions were relatively weak when compared with the sucrose consumption of saline-injected controls. The aversions extinguished rapidly within all groups. Contrary to earlier reports in rats, no sexual dimorphism in extinction rate was observed in this paradigm. When a fluid-deprivation schedule was implemented in the conditioning procedure to shorten the interval between taste experience and toxicosis, strong aversions were noted; yet relatively fast extinction under ad-lib conditions occurred in all groups except male DBA/2J mice. No sexual dimorphism was observed in mice of the C57BL/6J genotype, even when two pairings between sucrose and toxicosis were administered.
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Robbins, R. J.Sex-related differences in taste-aversion learning in deer mice. Paper presented at the meeting of the Psychonomic Society, Phoenix, Arizona, November 1979.
Ingram, D. K.Lithium chloride-induced taste aversions in C57BL/6J and DBA/2J mice. Paper presented at the meeting of the Southern Society for Philosophy and Psychology, Norfolk, Virginia, April 1979.
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This study was supported in part by a research grant, AG-00250, awarded to R. L. Sprott, and by General Funds of the Jackson Laboratory.
This research was conducted at the Jackson Laboratory while D. K. Ingram was a Postdoctoral Associate supported by a training grant, MH-12126, and a postdoctoral fellowship, AG-05171.
The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care.
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Ingram, D.K., Corfman, T.P. Strain-dependent sexual dimorphism in the extinction of conditioned taste aversion in mice. Animal Learning & Behavior 9, 101–107 (1981). https://doi.org/10.3758/BF03212031
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DOI: https://doi.org/10.3758/BF03212031