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Issues in the application of the average reference: Review, critiques, and recommendations

  • Joseph DienEmail author
Data Acquisition

Abstract

In standard event-related potential (ERP) recordings, activity at the reference site affects measurements at all the “active” electrode sites. Analyses of ERP data would be improved if reference site activity could be separated out. Apart from current source density methods, which can miss deep or distributed events, the major alternative to an “indifferent” electrode reference is one that combines all active electrodes, subtracting out the activity common to all of them. The average reference has merits (such as an insensitivity to scalp currents near any single electrode) and limitations (such as a dependence on the number and locations of all the electrodes in the average). This review compares the effects of different references on the scalp topography of the auditory N1 recorded with an array of 128 electrodes. Furthermore, it shows how assumptions associated with each reference affect inferential methods such as analysis of variance and correlation. Finally, it seeks to evaluate the efficacy of the average reference in estimating the true zero potential line.

Keywords

Reference Site Average Reference Recording Site Clinical Neurophysiology Current Source Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Andino, S. L. G., Marqui, R. D. P., Sosa, P. A. V., Lirio, R. B., Machado, C., Diaz, G., Rodriguez, P. F., &Torrez, C. C. (1990). Brain electrical field measurements unaffected by linked earlobes reference.Electroencephalography & Clinical Neurophysiology,75, 155–160.CrossRefGoogle Scholar
  2. Bertrand, O., Perrin, F., &Pernier, J. (1985). A theoretical justification of the average reference in topographic evoked potential studies.Electroencephalography & Clinical Neurophysiology,62, 462–464.CrossRefGoogle Scholar
  3. Bötzel, K., Schulze, S., &Stodieck, S. R. G. (1995). Scalp topography and analysis of intracranial sources of face-evoked potentials.Experimental Brain Research,104, 135–143.CrossRefGoogle Scholar
  4. Cattell, R. B. (1966). The scree test for the number of factors.Multivariate Behavioral Research,1, 245–276.CrossRefGoogle Scholar
  5. Cattell, R. B., &Jaspers, J. (1967). A general plasmode (No. 3010-5-2) for factor analytic exercises and research.Multivariate Behavioral Research Monographs, No. 67-3, pp. 1–212.Google Scholar
  6. Desmedt, J. E., Chalklin, V., &Tomberg, C. (1990). Emulation of somatosensory evoked potential (SEP) components with the 3-shell head model and the problem of “ghost potential fields” when using an average reference in brain mapping.Electroencephalography & Clinical Neurophysiology,77, 243–258.CrossRefGoogle Scholar
  7. Dien, J. (1997). Addressing misallocation of variance in principal components analysis of evoked potentials.Psychophysiology,34 (Suppl. 1), S31.Google Scholar
  8. Homan, R. W., Herman, J., &Purdy, P. (1987). Cerebral location of international 10–20 system electrode placement.Electroencephalography & Clinical Neurophysiology,66, 376–382.CrossRefGoogle Scholar
  9. Jeffreys, D. A. (1989). A face-responsive potential recorded from the human scalp.Experimental Brain Research,78, 193–202.CrossRefGoogle Scholar
  10. Katznelson, R. D. (1981). EEG recording, electrode placement, and aspects of generator localization. In P. L. Nunez (Ed.),Electric fields of the brain: The neurophysics of EEG (pp. 176–213). New York: Oxford University Press.Google Scholar
  11. Kooi, K. A., Tipton, A. C., &Marshall, R. E. (1971). Polarities and field configurations of the vertex components of the human auditory evoked response: A reinterpretation.Electroencephalography & Clinical Neurophysiology,31, 166–169.CrossRefGoogle Scholar
  12. Lehtonen, J. B., &Koivikko, M. J. (1971). The use of a non-cephalic reference electrode in recording cerebral evoked potentials in man.Electroencephalography & Clinical Neurophysiology,31, 154–156.CrossRefGoogle Scholar
  13. Loveless, N. E., Simpson, M., &Näätänen, R. (1987). Frontal negative and parietal positive components of the slow wave dissociated.Psychophysiology,24, 340–345.CrossRefPubMedGoogle Scholar
  14. Miller, G. A., Lutzenberger, W., &Elbert, T. (1991). The linked-reference issue in EEG and ERP recording.Journal of Psychophysiology,5, 273–276.Google Scholar
  15. Näätänen, R. (1992).Attention and brain function. Hillsdale, NJ: Erlbaum.Google Scholar
  16. Nunez, P. L. (1991). Comments on the paper by Miller, Lutzenberger and Elbert.Journal of Psychophysiology,5, 279–280.Google Scholar
  17. Offner, F. F. (1950). The EEG as potential mapping: The value of the average monopolar reference.Electroencephalography & Clinical Neurophysiology,2, 215–216.CrossRefGoogle Scholar
  18. Osselton, J. W. (1965). Acquisition of EEG data by bipolar, unipolar and average reference methods: A theoretical comparison.Electroencephalography & Clinical Neurophysiology,19, 527–528.CrossRefGoogle Scholar
  19. Perrin, F., Pernier, J., Bertrand, D., &Echallier, J. F. (1989). Spherical splines for scalp potential and current density mapping.Electroencephalography & Clinical Neurophysiology,72, 184–187.CrossRefGoogle Scholar
  20. Ruchkin, D. S., &Sutton, S. (1983). Positive slow wave and P300: Association and dissociation. In A. W. K. Gaillard & W. Ritter (Eds.),Tutorials in ERP research: Endogenous components (pp. 233–250). Amsterdam: North-Holland.CrossRefGoogle Scholar
  21. Squires, N. K., Squires, K. C., &Hillyard, S. A. (1975). Two varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man.Electroencephalography & Clinical Neurophysiology,38, 387–401.CrossRefGoogle Scholar
  22. Srinivasan, R., Tucker, D. M., &Murias, M. (1998). Estimating the spatial Nyquist of the human EEG.Behavior Research Methods, Instruments, & Computers,30, 8–19.Google Scholar
  23. Tomberg, C., Noel, P., Ozaki, I., &Desmedt, J. E. (1990). Inadequacy of the average reference for the topographic mapping of focal enhancements of brain potentials.Electroencephalography & Clinical Neurophysiology,77, 259–265.CrossRefGoogle Scholar
  24. Tucker, D. M. (1993). Spatial sampling of head electrical fields: The geodesic sensor net.Electroencephalography & Clinical Neurophysiology,87, 154–163.CrossRefGoogle Scholar
  25. Vaughan, H., &Ritter, W. (1970). The sources of auditory evoked responses recorded from the human scalp.Electroencephalography & Clinical Neurophysiology,28, 360–367.CrossRefGoogle Scholar
  26. Wolpaw, J. R., &Wood, C. W. (1982). Scalp distributions of human auditory evoked potentials: I. Evaluation of reference electrode sites.Electroencephalography & Clinical Neurophysiology,54, 15–24.CrossRefGoogle Scholar

Copyright information

© Psychonomic Society, Inc 1998

Authors and Affiliations

  1. 1.University of Illinois at Urbana-ChampaignUrbana

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