Abstract
A restraint and catheter-protection system consisting of a Plexiglas helmet and a nylon-tubing protector line has been developed to permit the long-term study of drug self-administration in monkeys. Frequent observations of monkeys in the system over a period exceeding a year have shown that the technique satisfies the requirements for long-term study of drug administration through an indwelling catheter and avoids several recurring problems inherent in other protection systems. Additional applications of the helmet and protector line are discussed.
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The development of this apparatus was supported by the Department of Justice, Bureau of Narcotics and Dangerous Drugs, and the 6571st Aeromedical Research Laboratory. However, the views expressed herein are those of the authors and do not necessarily reflect the views of the Department of Justice, the United States Air Force, or the Department of Defense.
Animals used in this study were handled in accordance with “guide for Laboratory Animal Facilities and Care,” prepared by the National Academy of Sciences-National Research Council and in accordance with the Secretary of Agriculture Standards in “Laboratory Animal Welfare.”
We wish to thanhk Dr. Douglas Ferraro for reading and earlier version of this manuscript.
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Talley, B., Trost, J. A Plexiglas helmet and catheter protection assembly for chronic intravenous administration of drugs in small primates. Behav. Res. Meth. & Instru. 2, 175–178 (1970). https://doi.org/10.3758/BF03209296
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DOI: https://doi.org/10.3758/BF03209296