Abstract
Discriminative stimuli produced by drugs control behavior in the same way as exteroceptive discriminative stimuli control behavior, despite the difficulty in controlling the intensity of the discriminative stimulus properties of drugs throughout test sessions. In recent years, many investigators have correlated the potency of drugs as discriminative stimuli, with their affinity for specific pharmacological receptors. High correlations have been interpreted as evidence that the discriminative stimulus properties of drugs are mediated by these specific pharmacological receptors. However, the relationship between discriminative stimulus potency and receptor affinity can be confounded by other pharmacological effects of drugs, such as their ability to produce position responding, and by behavioral variables, such as the schedule of reinforcement under which the drug discrimination is established and measured.
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Appel, J. B., &Dykstra, R. A. (1977). Drugs, discrimination and signal detection theory. In T. Thompson and P. B. Dews (Eds.).Advances in Behavioral Pharmacology, (Vol. 1, pp. 139–166). New York: Academic Press.
Cone, E. J., McQuinn, R. L., &Shannon, H. E. (1984). Structureactivity relationship studies on phencyclidine derivatives in rats.Journal of Pharmacology & Experimental Therapeutics,228, 147–153.
Friedman, R. L., Barrett, R. J., &Sanders-Bush, E. (1984). Discriminative stimulus properties of quipazine: Mediation by serotonin binding sites.Journal of Pharmacology & Experimental Therapeutics,228, 628–635.
Girden, E., &Culler, E. (1937). Conditioned responses in curarized striate muscles in dogs.Journal of Comparative Psychology,23, 261–274.
Jarbe, T.U.C., Johanson, J. O., &Henriksson, B. G. (1975). Drug discrimination in rats: The effects of phencyclidine and ditran.Psychopharmacologia,42, 33–39.
Jenkins, H. M. (1965). Measurement of stimulus control during discriminative operant conditioning.Psychological Bulletin,64, 365–376.
Kelleher, R. T., &Morse, W. H. (1968). Determinants of the specificity of behavioral effects of drugs.Ergebnisse der Physiologie, Biologischen Chemie und Experimentellen Pharmakologie,60, 1–56.
Laties, V. G. (1975). The role of discriminative stimuli in modulating drug action.Federation Proceedings,34, 1880–1888.
McKearney, J. W. (1979). Interrelations among prior experience and current conditions in the determination of behavior and the effects of drugs. In T. Thompson and P. B. Dews (Eds.),Advances in Behavioral Pharmacology, (Vol. 2, pp. 39–64). New York: Academic Press.
McMillan, D. E. (1982). Generalization of the discriminative stimulus properties of phencyclidine to other drugs in the pigeon using color tracking under second order schedules.Psychopharmacology,78, 131–134.
McMillan, D. E., Cole-Fullenwider, D. A., Hardwick, W. C., &Wenger, G. R. (1982). Phencyclidine discrimination in the pigeon using color tracking under second-order schedules.Journal of the Experimental Analysis of Behavior,37, 143–147.
McMillan, D. E., &Leander, J. D. (1976). Modification of baseline operant behavior by drugs. In S. D. Glick and J. Goldfarb (Eds.),Behavioral pharmacology (pp. 85–139). St. Louis, MO: Mosby.
McMillan, D. E., &Wenger, G. R. (1983). Effects of barbiturates and other sedative hypnotics in pigeons trained to discriminate phencydidine from saline.Journal of the Experimental Analysis of Behavior,40, 133–142.
McMillan, D. E., &Wenger, G. R. (1984). Bias of phencyclidine discrimination by the schedule of reinforcement.Journal of the Experimental Analysis of Behavior,42, 51–66.
Overton, D. A. (1975). A comparison of the discriminable CNS effects of ketamine, phencydidine and pentobarbital.Archives Internationales de Pharmacodynamie et de Therapie,215, 180–189.
Weissman, A., Milne, G. M., &Melvin, L. S., Jr. (1982). Cannabimimetic activity from CP-47, 497, a derivative of 3-phenylcyclohexanol.Journal of Pharmacology & Experimental Therapeutics,222, 516–523.
Young, A. M., Stephens, K. R., Hein, D. W., &Woods, J. H. (1984). Reinforcing and discriminative stimulus properties of mixed agonist-antagonist opioids.Journal of Pharmacology & Experimental Therapeutics,229, 118–126.
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Preparation of this review was supported by NIDA Grant DA 02251.
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McMillan, D.E. Behavioral and pharmacological influences on phencyclidine discrimination in the pigeon. Animal Learning & Behavior 17, 113–117 (1989). https://doi.org/10.3758/BF03205218
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DOI: https://doi.org/10.3758/BF03205218