Abstract
This report describes a computerized apparatus and procedure for completely automated noninvasive measurement of systolic, diastolic, and mean arterial blood pressure in conscious, unrestrained nonhuman primates. We used a specially constructed, cage-mounted oscillometric blood pressure instrument and operant reward conditioning methods to train adult baboons(Papio cynocephalus) to submit voluntarily to frequent self-initiated determinations of their blood pressures in the absence of a human operator/observer. Details concerning the operant training procedure and illustrative blood pressure data are presented. The accuracy of the method was evaluated by comparing the noninvasive blood pressure readings with simultaneously taken direct measurements obtained by means of chronically indwelling arterial catheters.
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Development of this method was supported by Specialized Center of Research in Arteriosclerosis Grant HL-19362 from the National Heart, Lung, and Blood Institute of the National Institutes of Health.
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Mitchell, D.S., Wigodsky, H.S., Peel, H.H. et al. Operant conditioning permits voluntary, noninvasive measurement of blood pressure in conscious, unrestrained baboons (Papio cynocephalus). Behavior Research Methods & Instrumentation 12, 492–498 (1980). https://doi.org/10.3758/BF03201822
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DOI: https://doi.org/10.3758/BF03201822