Psychonomic Bulletin & Review

, Volume 9, Issue 2, pp 239–249 | Cite as

Activity-based anorexia: Ambient temperature has been a neglected factor

Theoretical and Review Articles

Abstract

Activity-based anorexia refers to the self-starvation of rats exposed to experimental conditions that combine restricted access to food with access to an activity wheel. This paper compares previous studies of this phenomenon in relation to the ambient temperatures (AT) that were employed. On this basis, and from some more direct evidence, we argue that AT is an important, but neglected, factor in activity-based anorexia research. More attention to AT is needed in future research, since its neglect threatens the validity of conclusions drawn from those studies. Furthermore, direct examination of the effect of AT on activity-based anorexia will allow a better understanding of the mechanisms underlying this phenomenon and the possible clinical implications for the treatment of human anorexia nervosa.

References

  1. Ackerman, S. H., Hofer, M. A., &Weiner, H. (1978). Early maternal separation increases gastric ulcer risk in rats by producing a latent thermoregulatory disturbance.Science,201, 373–376.PubMedGoogle Scholar
  2. Altemus, M., Glowa, J. R., Galliven, E., Leong, Y., &Murphy, D. L. (1996). Effects of serotoninergic agents on food-restriction-induced hyperactivity.Pharmacology, Biochemistry & Behavior,53, 123–131.Google Scholar
  3. Aravich, P. F. (1996). Adverse effects of exercise stress and restricted feeding in the rat: Theoretical and neurobiological considerations. In W. F. Epling & W. D. Pierce (Eds.),Activity anorexia: Theory, research, and treatment (pp. 81–97). Mahwah, NJ: Erlbaum.Google Scholar
  4. Aravich, P. F., Rieg, T. S., Ahmed, I., &Lauterio, T. J. (1993). Fluoxetine induces vasopressin and oxytocin abnormalities in food-restricted rats given voluntary exercise: Relationships to anorexia nervosa.Brain Research,612, 180–189.PubMedGoogle Scholar
  5. Aravich, P. F., Rieg, T. S., Lauterio, T. J., &Doerries, L. E. (1993). b-endorphin and dynorphin abnormalities in rats subjected to exercise and restricted feeding: Relationship to anorexia nervosa.Brain Research,622, 1–8.PubMedGoogle Scholar
  6. Aravich, P. F., Stanley, E. Z., &Doerries, L. E. (1995). Exercise in food-restricted rats produces 2DG feeding and metabolic abnormalities similar to anorexia nervosa.Physiology & Behavior,57, 147–153.Google Scholar
  7. Bassøe, H. H. (1990). Anorexia/bulimia nervosa: The development of anorexia nervosa and the mental symptoms. Treatment and the outcome of the disease.Acta Psychiatrica Scandinavica,82, 7–13.Google Scholar
  8. Bell, R. (1985).Holy anorexia. Chicago: University of Chicago Press.Google Scholar
  9. Beneke, W. M., Schulte, S. E., &Vander Tuig, J. G. (1995). An analysis of excessive running in the development of activity anorexia.Physiology & Behavior,58, 451–457.Google Scholar
  10. Beneke, W. M., &Vander Tuig, J. G. (1996). Effects of dietary protein and food restriction on voluntary running of rats living in activity wheels. In W. F. Epling & W. D. Pierce (Eds.),Activity anorexia: Theory, research, and treatment (pp. 57–67). Mahwah, NJ: Erlbaum.Google Scholar
  11. Blundell, J. E., &King, N. A. (1999). Physical activity and regulation of food intake: Current evidence.Medicine & Science in Sports & Exercise,31, S573-S583.Google Scholar
  12. Blundell, J. E., &King, N. A. (2000). Exercise, appetite control, and energy balance.Nutrition,16, 519–522.PubMedGoogle Scholar
  13. Boakes, R. A., &Dwyer, D. M. (1997). Weight loss in rats produced by running: Effects of prior experience and individual housing.Quarterly Journal of Experimental Psychology,50B, 129–148.PubMedGoogle Scholar
  14. Boakes, R. A., Mills, K. J., &Single, J. P. (1999). Sex differences in the relationship between activity and weight loss in the rat.Behavioral Neuroscience,113, 1–10.Google Scholar
  15. Boer, D. P., Epling, W. F., Pierce, W. D., &Russell, J. C. (1990). Suppression of food deprivation-induced high-rate wheel running in rats.Physiology & Behavior,48, 339–342.Google Scholar
  16. Bolles, R. C., &Duncan, P. M. (1969). Daily course of activity and subcutaneous body temperature in hungry and thirsty rats.Physiology & Behavior,4, 87–89.Google Scholar
  17. Brobeck, J. R. (1945). Effects of variations in activity, food intake and environmental temperature on weight gain in the albino rat.American Journal of Physiology,143, 1–5.Google Scholar
  18. Brobeck, J. R. (1948). Food intake as a mechanism of temperature regulation.Yale Journal of Biology & Medicine,20, 545–552.Google Scholar
  19. Brobeck, J. R. (1960). Food and temperature. In G. Pincus (Ed.),Recent progress in hormone research (pp. 439–459). New York: Academic Press.Google Scholar
  20. Broocks, A., Liu, J., &Pirke, K. M. (1990). Semistarvation-induced hyperactivity compensates for decreased norepinephrine and dopamine turnover in the mediobasal hypothalamus of the rat.Journal of Neural Transmission,79, 113–124.PubMedGoogle Scholar
  21. Broocks, A., Schweiger, U., &Pirke, K. M. (1991). The influence of semistarvation-induced hyperactivity on hypothalamic serotonin metabolism.Physiology & Behavior,50, 385–388.Google Scholar
  22. Bruch, H. (1966).Eating disorders: Obesity, anorexia nervosa and the person within. London: Routledge & Kegan Paul.Google Scholar
  23. Campbell, B. A., &Lynch, G. S. (1967). Activity and thermoregulation during food deprivation in the rat.Physiology & Behavior,2, 311–313.Google Scholar
  24. Campbell, B. A., &Lynch, G. S. (1968). Influence of hunger and thirst on the relationship between spontaneous activity and body temperature.Journal of Comparative & Physiological Psychology,65, 492–498.Google Scholar
  25. Carlton, P. L., &Marks, R. A. (1958). Cold exposure and heat reinforced operant behavior.Science,28, 1344.Google Scholar
  26. Chossat, C. (1843). Recherches expérimentales sur l’inanition.Sciences Mathématiques et Psysiques,8, 438–640.Google Scholar
  27. Crisp, A. (1985). Arousal, physical activity, and energy balance in eating and body weight and shape disorders.International Journal of Eating Disorders,4, 627–649.Google Scholar
  28. Doerries, L. E., Aravich, P. F., Metkalf, V. A., Wall, J. D., &Lauterio, T. J. (1989). Beta endorphin and activity-based anorexia in the rat: Influence of simultaneously initiated dieting and exercise on weight loss and beta endorphin. In L. H. Schneider, S. J. Cooper, & K. A. Halmi (Eds.),The psychobiology of human eating disorders: Preclinical and clinical perspectives (Annals of the New York Academy of Sciences, Vol. 575, pp. 609–610). New York: New York Academy of Sciences.Google Scholar
  29. Doerries, L. E., Stanley, E. Z., &Aravich, P. F. (1991). Activitybased anorexia: Relationship to gender and activity-stress ulcers.Physiology & Behavior,50, 945–949.Google Scholar
  30. Dwyer, D. M., &Boakes, R. A. (1997). Activity-based anorexia in rats as a failure to adapt to a feeding schedule.Behavioral Neuroscience,111, 195–205.PubMedGoogle Scholar
  31. Epling, W. F., &Pierce, W. D. (1984). Activity-based anorexia in rats as a function of opportunity to run on an activity wheel.Nutrition & Behaviour,2, 37–49.Google Scholar
  32. Epling, W. F., &Pierce, W. D. (1991).Solving the anorexia puzzle: A scientific approach. Toronto: Hogrefe & Huber.Google Scholar
  33. Epling, W. F., &Pierce, W. D. (1996).Activity anorexia: Theory, research, and treatment. Mahwah, NJ: Erlbaum.Google Scholar
  34. Epling, W. F., Pierce, W. D., &Stefan, L. A. (1981). Schedule-induced self-starvation. In C. M. Bradshaw, E. Szabadi, & C. F. Lowe (Eds.),Quantification of steady-state operant behaviour (pp. 393–396). Amsterdam: North-Holland.Google Scholar
  35. Epling, W. F., Pierce, W. D., &Stefan, L. A. (1983). A theory of activity-based anorexia.International Journal of Eating Disorders,3, 27–46.Google Scholar
  36. Escamilla, R. F. (1944). Anorexia nervosa or Simmonds’ Disease? Notes on clinical management with some points of differentiation between the two conditions.Journal of Nervous & Mental Disease,99, 583–587.Google Scholar
  37. Farquharson, R. F., &Hyland, H. H. (1938). Anorexia nervosa: Metabolic disorder of psychologic origin.Journal of the American Medical Association,111, 1085–1092.Google Scholar
  38. Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G., &Munoz, R. (1972). Diagnostic criteria for use in psychiatric research.Archives of General Psychiatry,26, 57–63.PubMedGoogle Scholar
  39. Glavin, G. B., &Paré, W. P. (1985). Early weaning predisposes rats to exacerbated activity-stress ulcer formation.Physiology & Behavior,34, 907–909.Google Scholar
  40. Gordon, C. J. (1990). Thermal biology of the laboratory rat.Physiology & Behavior,47, 963–991.Google Scholar
  41. Gull, W. (1874). Anorexia nervosa (apepsia hysterica, anorexia hysterica).Transactions of the Clinical Society of London,7, 22–28.Google Scholar
  42. Gutiérrez, E., &Vázquez, R. (2001). Effects of heat treatment in anorexia nervosa when hyperactivity is a salient feature.Eating & Weight Disorders,6, 49–52.Google Scholar
  43. Hall, R. C. W., &Beresford, T. P. (1989). Medical complications of anorexia and bulimia.Psychiatric Medicine,7, 165–192.PubMedGoogle Scholar
  44. Hamilton, C. L. (1959). Effect of food deprivation on thermal behavior of the rat.Proceedings of the Society of Experimental Biology & Medicine,100, 354–356.Google Scholar
  45. Hamilton, C. L. (1969). Problems of refeeding after starvation in the rat. In P. J. Morgane et al. (Eds.),Neural regulation of food and water intake (Annals of the New York Academy of Sciences, Vol. 157, pp. 1004–1017). New York: New York Academy of Sciences.Google Scholar
  46. Hamilton, C. L., &Brobeck, J. R. (1964). Food intake and temperature regulation in rats with rostral hypothalamic lesions.American Journal of Physiology,207, 291–297.PubMedGoogle Scholar
  47. Hara, C., Manabe, K., &Ogawa, N. (1981). Influence of activitystress on thymus, spleen and adrenal weights of rats: Possibility for an immunodeficiency model.Physiology & Behavior,27, 243–248.Google Scholar
  48. Hara, C., &Ogawa, N. (1981). The activity-stress ulcer and antibody production in rats.Physiology & Behavior,27, 1609–1613.Google Scholar
  49. Hara, C., &Ogawa, N. (1983). Influence of maturation on ulcerdevelopment and immunodeficiency induced by activity-stress in rats.Physiology & Behavior,30, 757–761.Google Scholar
  50. Hara, C., &Ogawa, N. (1984). Effects of psychotropic drugs on the development of activity-stress ulcer in rats.Japanese Journal of Pharmacology,35, 474–477.PubMedGoogle Scholar
  51. Houser, V. P., Cash, R. J., &Van Hart, A. (1975). Effects of manipulating cholinergic tone upon the activity-stress ulcer.Pharmacology, Biochemistry & Behavior,3, 825–831.Google Scholar
  52. Ibuka, N., Inouye, S. T., &Kawamura, H. (1977). Analyses of sleep wakefulness rhythms in rats with preoptic lesions.Brain Research,122, 33–47.PubMedGoogle Scholar
  53. King, A. (1963). Primary and secondary anorexia nervosa syndromes.British Journal of Psychiatry,109, 470–479.PubMedGoogle Scholar
  54. Kissileff, H. R., Pi-Sunyer, F. X., Segal, K., Meltzer, S., &Foelsch, P. A. (1990). Acute effects of exercise on food intake in obese and nonobese women.American Journal of Clinical Nutrition,52, 240–245.PubMedGoogle Scholar
  55. Koh, M. T., Lett, B. T., &Grant, V. L. (2000). Activity in the circular alley does not produce the activity anorexia syndrome in rats.Appetite,34, 153–159.PubMedGoogle Scholar
  56. Lambert, K. G. (1993). The activity-stress paradigm: Possible mechanisms and applications.Journal of General Psychology,120, 21–32.PubMedGoogle Scholar
  57. Lambert, K. G., & Hanrahan, L. (1990, April).The effect of ambient temperature on the activity-stress ulcer paradigm. Paper presented at the meeting of the Southern Society for Philosophy and Psychology, Louisville, KY.Google Scholar
  58. Lambert, K. G., &Kingsley, C. H. (1993). Sex differences and gonadal hormones influence susceptibility to the activity-stress paradigm.Physiology & Behavior,53, 1085–1090.Google Scholar
  59. Lambert, K. G., &Peacock, L. J. (1989). Feeding regime affects activitystress ulcer production.Physiology & Behavior,48, 743–746.Google Scholar
  60. Lambert, K. G., &Porter, J. H. (1992). Pimozide mitigates excessive running in the activity-stress paradigm.Physiology & Behavior,52, 299–304.Google Scholar
  61. Lasègue, C. (1873). De l’anorexie hystérique.Archives Générales de Médicine,21, 385–403. [English translation in M. R. Kaufman & M. Heiman (Eds.),Evolution of psychosomatic concepts (pp. 141–155). New York: International University Press, 1964.]Google Scholar
  62. Levitsky, D., &Collier, G. (1968). Schedule-induced wheel running.Physiology & Behavior,3, 571–573.Google Scholar
  63. Morrow, N. S., Schall, M., Grijalva, C. V., Geiselman, P. J., Garrick, T., Nuccion, S., &Novin, D. (1997). Body temperature and wheel running predict survival times in rats exposed to activity-stress.Physiology & Behavior,62, 815–825.Google Scholar
  64. Morse, A. D., Russell, J. C., Hunt, T. W. M., Wood, G. O., Epling, W. F., &Pierce, W. D. (1995). Diurnal variation of intensive running in food-deprived rats.Canadian Journal of Physiology & Pharmacology,73, 1519–1523.Google Scholar
  65. Mrosovsky, N., &Sherry, D. F. (1980). Animal anorexias.Science,207, 837–842.PubMedGoogle Scholar
  66. Paré, W. P. (1974). Feeding environment and the activity-stress ulcer.Bulletin of the Psychonomic Society,4, 546–548.Google Scholar
  67. Paré, W. P. (1975). The influence of food consumption and running activity on the activity-stress ulcer in the rat.Digestive Diseases,20, 262–273.Google Scholar
  68. Paré, W. P. (1976). Activity-stress ulcer in the rat: Frequency and chronicity.Physiology & Behavior,16, 699–704.Google Scholar
  69. Paré, W. P. (1977a). Body temperature and the activity-stress ulcer in the rat.Physiology & Behavior,18, 219–223.Google Scholar
  70. Paré, W. P. (1977b). Gastric secretion and A-S lesions in the rat.Journal of Comparative & Physiological Psychology,91, 778–783.Google Scholar
  71. Paré, W. P. (1978). Effects of cimetidine on stress ulcer and gastric acid secretion in the rat.Pharmacology, Biochemistry & Behavior,8, 711–715.Google Scholar
  72. Paré, W. P. (1980). Psychological studies of stress ulcer in the rat.Brain Research Bulletin,5, 73–79.PubMedGoogle Scholar
  73. Paré, W. P. (1986). Prior stress and susceptibility to stress ulcer.Physiology & Behavior,36, 1155–1159.Google Scholar
  74. Paré, W. P. (1988). A comparison of two ulcerogenic techniques.Physiology & Behavior,44, 417–420.Google Scholar
  75. Paré, W. P. (1989). ‘Behavioral despair’ test predicts stress ulcer in WKY rats.Physiology & Behavior,46, 483–487.Google Scholar
  76. Paré, W. P., &Glavin, G. B. (1986). Restraint stress in biomedical research: A review.Neuroscience & Biobehavioral Reviews,10, 339–370.Google Scholar
  77. Paré, W. P., &Houser, V. P. (1973). Activity and food-restriction effects on gastric glandular lesions in the rat: The activity-stress ulcer.Bulletin of the Psychonomic Society,2, 213–214.Google Scholar
  78. Paré, W. P., Natelson, B. H., Vincent, G. P., &Isom, K. E. (1980). A clinical evaluation of rats dying in the A-S ulcer paradigm.Physiology & Behavior,25, 417–420.Google Scholar
  79. Paré, W. P., &Valdsaar, E. (1985). The effects of housing and preshock on activity-stress ulcer.Physiological Psychology,13, 33–36.Google Scholar
  80. Paré, W. P., &Vincent, G. P. (1981). The activity-stress ulcer model. In S. Umeare & H. Ito (Eds.),Advances in experimental ulcer (pp. 93–116). Tokyo: Tokyo Medical College Press.Google Scholar
  81. Paré, W. P., &Vincent, G. P. (1989). Environmental enrichment, running behavior and A-S ulcer in the rat.Medical Science Research,17, 35–36.Google Scholar
  82. Paré, W. P., Vincent, G. P., Isom, K. E., &Reeves, J. M. (1978). Sex differences and incidence of activity-stress ulcer in the rat.Psychological Reports,43, 591–594.PubMedGoogle Scholar
  83. Paré, W. P., Vincent, G. P., &Natelson, B. H. (1985). Daily feeding schedule and housing on incidence of activity-stress ulcer.Physiology & Behavior,34, 423–429.Google Scholar
  84. Pierce, W. D., &Epling, W. F. (1991). Activity anorexia: An animal model and theory of human self-starvation. In A. Boulton, G. Baker, & M. Martin-Iverson (Eds.),Neuromethods: Animal models in psychiatry, I (Vol. 18, pp. 267–311). Clifton, NJ: Humana.Google Scholar
  85. Pierce, W. D., &Epling, W. F. (1994). Activity anorexia: An interplay between basic and applied behavior analysis.The Behavior Analyst,17, 7–23.Google Scholar
  86. Pierce, W. D., Epling, W. F., &Boer, D. P. (1986). Deprivation and satiation: The interrelations between food and wheel running.Journal of the Experimental Analysis of Behaviour,46, 199–210.Google Scholar
  87. Pirke, K. M. (1996). The role of neurotransmitters in activity anorexia in the rat. In W. F. Epling & W. D. Pierce (Eds.),Activity anorexia: Theory, research, and treatment (pp. 99–111). Mahwah, NJ: Erlbaum.Google Scholar
  88. Richard, D., &Rivest, S. (1989). The role of exercise in thermogenesis and energy balance.Canadian Journal of Physiology & Pharmacology,67, 402–409.Google Scholar
  89. Rivest, S., &Richard, D. (1990). Involvement of corticotropinreleasing factor in the anorexia induced by exercise.Brain Research Bulletin,25, 169–172.PubMedGoogle Scholar
  90. Routtenberg, A. (1968). Self-starvation of rats living in activity wheels: Adaptation effects.Journal of Comparative & Physiological Psychology,66, 234–238.Google Scholar
  91. Routtenberg, A., &Kuznesof, A. (1967). Self-starvation of rats living in activity wheels on a restricted feeding schedule.Journal of Comparative & Physiological Psychology,64, 414–421.Google Scholar
  92. Russell, J. C., &Morse, A. D. (1996). The induction and maintenance of hyperactivity during food restriction in rats. In W. F. Epling & W. D. Pierce (Eds.),Activity anorexia: Theory, research, and treatment (pp. 113–121). Mahwah, NJ: Erlbaum.Google Scholar
  93. Sherwin, C. M. (1998). Voluntary wheel running: A review and novel interpretation.Animal Behavior,56, 11–27.Google Scholar
  94. Spatz, C., &Jones, S. D. (1971). Starvation anorexia as an explanation of “self-starvation” of rats living in activity wheels.Journal of Comparative & Physiological Psychology,77, 313–317.Google Scholar
  95. Stevenson, J. A., Box, B. M., Feleki, V., &Beaton, J. R. (1966). Bouts of exercise and food intake in the rat.Journal of Applied Physiology & Psychology,21, 118–122.Google Scholar
  96. Stevenson, J. A., &Rixon, R. (1957). Environmental temperature and deprivation of food and water on the spontaneous activity of rats.Yale Journal of Biological Medicine,29, 575–584.Google Scholar
  97. Thompson, G. E., &Stevenson, J. A. F. (1963). The effect of food deprivation on temperature regulation in exercise.Canadian Journal of Biochemistry & Physiology,41, 528–530.Google Scholar
  98. Treasure, J. L., &Owen, J. B. (1997). Intriguing links between animal behavior and anorexia nervosa.International Journal of Eating Disorders,21, 307–311.PubMedGoogle Scholar
  99. Tsuda, A., Tanaka, M., Jimori, K., Ida, Y., &Nagasaki, N. (1981). Effects of divided feeding on activity-stress ulcer and the thymus weight in the rat.Physiology & Behavior,27, 349–353.Google Scholar
  100. Vincent, G. P., &Paré, W. P. (1976). Activity-stress ulcer in the rat, hamster, gerbil and guinea pig.Physiology & Behavior,16, 557–560.Google Scholar
  101. Watanabe, K., Hara, C., &Ogawa, N. (1990). Relationship between running activity rhythm and the development of activity-stress ulcer in rats.Japanese Journal of Pharmacology,52, 421–429.PubMedGoogle Scholar
  102. Watanabe, K., Hara, C., &Ogawa, N. (1992). Feeding conditions and estrous cycle of female rats under the A-S stress procedure from aspects of anorexia nervosa.Physiology & Behavior,51, 827–832.Google Scholar
  103. Weiss, B. (1957). Thermal behavior of the subnourished and pantothenicacid deprived rat.Journal of Comparative & Physiological Psychology,50, 481–485.Google Scholar
  104. Weiss, B., &Laties, V. G. (1960). Magnitude of reinforcement as a variable in thermoregulatory behavior.Journal of Comparative & Physiological Psychology,53, 603–608.Google Scholar
  105. Weiss, B., &Laties, V. G. (1961). Behavioral thermoregulation.Science,133, 1338–1344.PubMedGoogle Scholar
  106. Yi, I., &Stephan, F. K. (1996). Body fat reserves attenuate gastric ulcers induced by restricted feeding in rats.Physiology & Behavior,59, 931–936.Google Scholar
  107. Yi, I., Stephan, F. K., &Bays, M. E. (1995). Activity-stress ulcers in rats: The role of preentrainment to meal time.Physiology & Behavior,58, 67–73.Google Scholar

Copyright information

© Psychonomic Society, Inc. 2002

Authors and Affiliations

  • Emilio Gutiérrez
    • 1
  • Reyes Vázquez
    • 2
  • R. A. Boakes
    • 3
  1. 1.Departamento de Psicología Clínica y Psicobiología, Facultad de PsicologíaUniversidad de SantiagoSantiago de CompostelaSpain
  2. 2.UNED PontevedraSpain
  3. 3.University of SydneySydneyAustralia

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