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The push and pull of dopamine in cue-reward learning

  • Sean B. OstlundEmail author
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Summary

A recent study by Saunders, Richard, Margolis, and Janak (2018) shows that there is a great deal left to learn about what different mesotelencephalic dopamine circuits contribute to learning about the motivational significance of reward-related cues. Their findings suggest that nigrostriatal and mesolimbic dopamine pathways support distinct reinforcement processes that independently push and pull animals toward their goals.

Keywords

Incentive motivation General arousal Optogenetics Reinforcement Pavlovian 

References

  1. Berridge, K. C. (2012). From prediction error to incentive salience: Mesolimbic computation of reward motivation. European Journal of Neuroscience, 35(7), 1124–1143.  https://doi.org/10.1111/j.1460-9568.2012.07990.x CrossRefPubMedGoogle Scholar
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  3. Ostlund, S. B., & Maidment, N. T. (2011). Dopamine receptor blockade attenuates the general incentive motivational effects of noncontingently delivered rewards and reward-paired cues without affecting their ability to bias action selection. Neuropsychopharmacology, 37, 508.  https://doi.org/10.1038/npp.2011.217 CrossRefPubMedPubMedCentralGoogle Scholar
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  5. Saunders, B. T., Richard, J. M., Margolis, E. B., & Janak, P. H. (2018). Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties. Nature Neuroscience, 21(8), 1072–1083.  https://doi.org/10.1038/s41593-018-0191-4 CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© The Psychonomic Society, Inc. 2019

Authors and Affiliations

  1. 1.Department of Anesthesiology and Perioperative Care and Irvine Center for Addiction NeuroscienceUniversity of California, IrvineIrvineUSA

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