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Individual differences in dopamine D2 receptor availability correlate with reward valuation

  • Linh C. Dang
  • Gregory R. Samanez-Larkin
  • Jaime J. Castrellon
  • Scott F. Perkins
  • Ronald L. Cowan
  • David H. Zald
Article

Abstract

Reward valuation, which underlies all value-based decision-making, has been associated with dopamine function in many studies of nonhuman animals, but there is relatively less direct evidence for an association in humans. Here, we measured dopamine D2 receptor (DRD2) availability in vivo in humans to examine relations between individual differences in dopamine receptor availability and neural activity associated with a measure of reward valuation, expected value (i.e., the product of reward magnitude and the probability of obtaining the reward). Fourteen healthy adult subjects underwent PET with [18F]fallypride, a radiotracer with strong affinity for DRD2, and fMRI (on a separate day) while performing a reward valuation task. [18F]fallypride binding potential, reflecting DRD2 availability, in the midbrain correlated positively with neural activity associated with expected value, specifically in the left ventral striatum/caudate. The present results provide in vivo evidence from humans showing midbrain dopamine characteristics are associated with reward valuation.

Keywords

Reward valuation Dopamine Ventral striatum Midbrain 

Notes

Acknowledgements

This work was supported by the National Institute on Aging (R01AG044838 to DHZ, R00AG042596 to G.R.S.L.), the National Institute on Drug Abuse (F32DA036979 to L.C.D.), and the Vanderbilt Institute for Clinical and Translational Research which receives funding from the National Center for Advancing Translational Sciences. Funding institutes were not involved in the collection, analysis and interpretation of data, in the writing of the report, and in the decision to submit the article for publication.

Compliance with ethical standards

Conflict of interest

None

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Copyright information

© Psychonomic Society, Inc. 2018

Authors and Affiliations

  • Linh C. Dang
    • 1
  • Gregory R. Samanez-Larkin
    • 2
  • Jaime J. Castrellon
    • 2
  • Scott F. Perkins
    • 1
  • Ronald L. Cowan
    • 3
    • 4
  • David H. Zald
    • 1
    • 3
  1. 1.Department of PsychologyVanderbilt UniversityNashvilleUSA
  2. 2.Department of Psychology and NeuroscienceDuke UniversityDurhamUSA
  3. 3.Department of Psychiatry and Behavioral SciencesVanderbilt University School of MedicineNashvilleUSA
  4. 4.Department of Radiology and Radiological SciencesVanderbilt University Medical CenterNashvilleUSA

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