Dopamine D2 agonist affects visuospatial working memory distractor interference depending on individual differences in baseline working memory span

  • James M. Broadway
  • Michael J. Frank
  • James F. Cavanagh
Article

Abstract

The interplay of dopaminergic striatal D1–D2 circuits is thought to support working memory (WM) by selectively filtering information that is to be remembered versus information to be ignored. To test this theory, we conducted an experiment in which healthy participants performed a visuospatial working memory (VSWM) task after ingesting the D2-receptor agonist cabergoline (or placebo), in a randomized, double-blinded, crossover design. Results showed greater interference from distractors under cabergoline, particularly for individuals with higher baseline dopamine (indicated by WM span). These findings support computational theories of striatal D1–D2 function during WM encoding and distractor-filtering, and provide new evidence for interactive cortico-striatal systems that support VSWM capacity and their dependence on WM span.

Keywords

Agonist Basal ganglia Cabergoline Capacity Dopamine D2 Individual differences Prefrontal cortex Striatum Visuospatial working memory Working memory 

Notes

Acknowledgements

This study was supported by National Science Foundation (NSF) 1125788 and National Institute of General Medical Sciences (NIGMS) 1P20GM109089-01A1.

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Copyright information

© Psychonomic Society, Inc. 2018

Authors and Affiliations

  • James M. Broadway
    • 1
  • Michael J. Frank
    • 2
  • James F. Cavanagh
    • 1
  1. 1.Department of NeurosciencesUniversity of New MexicoAlbuquerqueUSA
  2. 2.Brown UniversityProvidenceUSA

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