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Evidence for working memory storage operations in perceptual cortex

  • Kartik K. Sreenivasan
  • Caterina Gratton
  • Jason Vytlacil
  • Mark D’Esposito
Article

Abstract

Isolating the short-term storage component of working memory (WM) from the myriad of associated executive processes has been an enduring challenge. Recent efforts have identified patterns of activity in visual regions that contain information about items being held in WM. However, it remains unclear (1) whether these representations withstand intervening sensory input and (2) how communication between multimodal association cortex and the unimodal perceptual regions supporting WM representations is involved in WM storage. We present evidence that the features of a face held in WM are stored within face-processing regions, that these representations persist across subsequent sensory input, and that information about the match between sensory input and a memory representation is relayed forward from perceptual to prefrontal regions. Participants were presented with a series of probe faces and indicated whether each probe matched a target face held in WM. We parametrically varied the feature similarity between the probe and target faces. Activity within face-processing regions scaled linearly with the degree of feature similarity between the probe face and the features of the target face, suggesting that the features of the target face were stored in these regions. Furthermore, directed connectivity measures revealed that the direction of information flow that was optimal for performance was from sensory regions that stored the features of the target face to dorsal prefrontal regions, supporting the notion that sensory input is compared to representations stored within perceptual regions and is subsequently relayed forward. Together, these findings indicate that WM storage operations are carried out within perceptual cortex.

Keywords

Working memory Functional connectivity 

Supplementary material

13415_2013_246_MOESM1_ESM.pdf (100 kb)
Figure S1 (PDF 100 kb)
13415_2013_246_MOESM2_ESM.docx (68 kb)
Table S1 (DOCX 68.0 KB)

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Copyright information

© Psychonomic Society, Inc. 2014

Authors and Affiliations

  • Kartik K. Sreenivasan
    • 1
    • 2
  • Caterina Gratton
    • 1
  • Jason Vytlacil
    • 1
  • Mark D’Esposito
    • 1
  1. 1.Helen Wills Neuroscience InstituteUniversity of CaliforniaBerkeleyUSA
  2. 2.Division of Science and MathematicsNew York University Abu DhabiAbu DhabiUnited Arab Emirates

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