Physiological Psychology

, Volume 13, Issue 3, pp 118–126 | Cite as

Behavioral functions of locus coeruleus derived from cellular attributes

  • Gary Aston-Jones
The Locus Ceoruleus
  • 237 Downloads

Abstract

The electrophysiological activity of noradrenergic neurons in the locus coeruleus (LC) was examined in unanesthetized rats during spontaneously occurring behavior and sensory stimulation. The pattern of spontaneous and evoked discharge during sleep, grooming, drinking, and orienting behaviors, considered in light of other cellular anatomic and physiologic attributes, implicates the LC system in the control of vigilance and initiation of adaptive behavioral responses.

References

  1. Aghajanian, G. K., Vandermaelen, C. P., & Andarde, R. (1983). Intracellular studies on the role of calcium in regulating the activity and reactivity of locus coeruleus neurons in vivo. Brain Research, 273, 237–243.PubMedCrossRefGoogle Scholar
  2. Aston-Jones, G., & Bloom, F. E. (1981a). Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. Journal of Neuroscience, 1, 876–886.PubMedGoogle Scholar
  3. Aston-Jones, G., & Bloom, F. E., (1981b). Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to nonnoxious environmental stimuli. Journal of Neuroscience, 1, 887–900.PubMedGoogle Scholar
  4. Aston-Jones, G., Foote, S. L., & Bloom, F. E. (1984). Anatomy and physiology of locus coeruleus neurons: Functional implications. In M. Ziegler & C. Lake (Eds.), Frontiers in clinical neuroscience: Vol. 2. Norepinephrine (pp. 92–116). Baltimore: Williams & Wilkins.Google Scholar
  5. Beaudet, A., & Descarries, L. (1978). The monoamine innervations of rat cerebral cortex: Synaptic and nonsynaptic axons terminals. Neuroscience, 3, 851–860.PubMedCrossRefGoogle Scholar
  6. Britton, D. R., Ksir, C., Thatcher-Britton, K., Young, D., & Koob, G. F. (1984). Brain norepinephrine depleting lesions selectively enhance behavioral responsiveness to novelty. Physiology & Behavior, 33, 473–478.CrossRefGoogle Scholar
  7. Chase, M. (1980). The motor functions of the reticular system are multifaceted and state-determined. In J. Hobson & M. Brazier (Eds.), The reticular system revisited (pp. 449–472).New York: Raven Press.Google Scholar
  8. Chu, N.-S., & Bloom, F. E. (1973). Norepinephrine-containing neu- rons: Changes in spontaneous discharge patterns during sleeping and waking. Science, 179, 908–910.PubMedCrossRefGoogle Scholar
  9. Chu, N.-S., & Bloom, F. E. (1974). Activity patterns of catecholamine-containing pontine neurons in the dorsolateral tegmentum of unrestrained cats. Journal of Neurobiology, 5, 527–544.PubMedCrossRefGoogle Scholar
  10. Everitt, B. J., Robbins, T. W., Gaskin, M., & Fray, P. J. (1983). The effects of lesions to ascending noradrenergic neurons on discrimination learning and performance in the rat, Neuroscience, 10, 397–410.PubMedCrossRefGoogle Scholar
  11. Foote, S. L., Aston-Jones, G., & Bloom, F. E. (1980). Impulse activity of locus coeruleus neurons in awake rats and squirrel monkeys is a function of sensory stimulation and arousal. Proceedings of the National Academy of Sciences (USA), 77, 3033–3037.CrossRefGoogle Scholar
  12. Foote, S. L., Bloom, F. E., & Aston-Jones, G. (1983). The nucleus locus coeruleus: New evidence of anatomical and physiological specificity. Physiological Reviews, 63, 844–914.PubMedGoogle Scholar
  13. Foote, S. L., Friedman, R., & Oliver, A. P. (1975). Effects of putative neurotransmitters on neuronal activity in monkey cerebral cortex. Brain Research, 86, 229–242.PubMedCrossRefGoogle Scholar
  14. Fuller, R. W., & Putnam, P. (1966). On the origin of order in behavior. General Systems, 11, 99–112.Google Scholar
  15. Hobson, J., McCarley, R., & Wyzinski, P. (1975). Sleep cycle oscillation: Reciprocal discharge by two brainstem groups. Science, 189, 55–58.PubMedCrossRefGoogle Scholar
  16. Jacobs, B. L., Rasmussen, K., & Morilak, D. (1984). Locus coeruleus activity in cat: Behavioral and state correlates. Society for Neuroscience Abstracts, 14, 1174.Google Scholar
  17. Jouvet, M. (1969). Biogenic amines and the states of sleep. Science, 163, 32–41.PubMedCrossRefGoogle Scholar
  18. Koda, L. Y., Schulman, J. A., & Bloom, F. E. (1978). Ultrastruc-tural identification of noradrenergic terminals in the rat hippocampus: Unilateral destruction of the locus coeruleus with 6-hydroxydopamine. Brain Research, 145, 190–195.PubMedCrossRefGoogle Scholar
  19. McCarley, R. W., & Hobson, J. A. (1975). Neuronal excitability modulation over the sleep cycle: A structural and mathematical model Science, 189, 58–60.PubMedCrossRefGoogle Scholar
  20. Morrison, J. H., Foote, S. L., O’Connor, D., & Bloom, F. E. (1982). Laminar, tangential and regional organization of the noradrenergic innervation of monkey cortex: Doparnine-beta-hydroxylase immuno-histochemistry. Brain Research Bulletin, 9, 309–319.PubMedCrossRefGoogle Scholar
  21. Olschowka, J., Molliver, M., Grzanna, R., Rice, F., & Molliver, M. (1981). Ultrastructural demonstration of noradrenergic synapses in the rat central nervous system by dopamine-beta-hydroxylase immunocytochemistry. Journal of Histochemistry & Cytochemistry, 29, 271–280.CrossRefGoogle Scholar
  22. Robbins, T. W. (1984). Cortical noradrenaline, attention and arousal. Psychological Medicine, 14, 13–21.PubMedCrossRefGoogle Scholar
  23. Sara, S. J. (1985). The locus coeruleus and cognitive function: Attempts to relate noradrenergic enhancement of signal/noise in the brain to behavior. Physiological Psychology, 13, 151–162.Google Scholar
  24. Segal, M. (1985). Mechanisms of action of noradrenaline in the brain. Physiological Psychology, 13, 172–178.Google Scholar
  25. Steriade, M., & Hobson, J. (1976). Neuronal activity during the sleepwaking cycle. Progress in Neurobiology, 6, 155–376.PubMedCrossRefGoogle Scholar
  26. Williams, J., Egan, T., & North, R. (1982). Enkephalin opens potassium channels on mammalian central neurones. Nature, 299, 74–77.PubMedCrossRefGoogle Scholar
  27. Williams, J., Henderson, G., & North, A. (1984). Locus coeruleus neurons. In R. Dingledine (Ed.), Brain slices (pp. 297–311). New York: Plenum Press.CrossRefGoogle Scholar

Copyright information

© Psychonomic Society, Inc. 1986

Authors and Affiliations

  • Gary Aston-Jones
    • 1
  1. 1.Department of Biology, Washington Square Center for Neural ScienceNew York UniversityNew York

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