Quantification of brain lesions using interactive automated software

  • Milan Makale
  • Jeffrey Solomon
  • Nicholas J. Patronas
  • Adrian Danek
  • John A. Butman
  • Jordan Grafman
Article

DOI: 10.3758/BF03195419

Cite this article as:
Makale, M., Solomon, J., Patronas, N.J. et al. Behavior Research Methods, Instruments, & Computers (2002) 34: 6. doi:10.3758/BF03195419
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Abstract

We developed an interactive program, Analysis of Brain Lesions (ABLe) so that researchers studying the effects of brain lesions on cognition could have a user-friendly tool that could quantitatively characterize such lesions. The program was prepared in Tcl/Tk and will run on any UNIX or PC LINUX platform with the MEDx medical imaging software package. The ABLe is almost completely automated and determines the brain lesion size as well as which cytoarchitectonic brain regions (Brodmann areas) are contained within the boundaries of the lesion. Lesion data from multiple subjects can be grouped together and the degree of lesion overlap displayed. All images are analyzed and displayed within standard Talairach coordinate space, and the precision of the match between the ABLe Brodmann area graphics and the subject/patient brain is easily confirmed. The program is the first easy-to-use software that contains these specific features and is available for interested researchers with a background in lesion analysis.

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Copyright information

© Psychonomic Society, Inc. 2002

Authors and Affiliations

  • Milan Makale
    • 1
    • 3
  • Jeffrey Solomon
    • 2
  • Nicholas J. Patronas
    • 3
  • Adrian Danek
    • 3
  • John A. Butman
    • 3
  • Jordan Grafman
    • 3
  1. 1.H. M. Jackson FoundationBethesda
  2. 2.Sensor Systems IncorporatedSterling
  3. 3.Cognitive Neuroscience Section, National Institute for Neurological Disorders and StrokeNational Institutes of HealthBethesda

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