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Effect of mechanical and metabolic factors on motor function and fatigue in obese men and women: A cross-sectional study

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Abstract

Background: Mechanical overload and poor quality of contractile elements related to metabolic abnormalities concur to motor disability of obesity. The independent contribution of these factors to motor dysfunction in obese individuals is scarcely defined. Aim: Aim of the study is to test the hypothesis that metabolic factors may independently affect motor function in obesity. Methods: Leg maximum power output per unit body mass (Ẇmb), per unit fat-free mas (Ẇffm) and fatigue in daily functioning were assessed in 635 obese [body mass index (BMI)≥35 kg/m2] individuals (286 men, 349 women) aged 19–78 yr. The independent effects of age, BMI, insulin resistance and the five components of the metabolic syndrome on Ẇmb, Ẇffm and fatigue were evaluated by multivariate analysis. Results: A multiple regression analysis revealed that in both genders Ẇmb (denoting the individual’s performance capability during anaerobic tasks) was independently reduced by age (p<0.001), BMI (p<0.05–0.001) and abnormalities of glucose metabolism (p<0.06–0.01), while Ẇffm (representing the muscle intrinsic anaerobic capability) was affected only by age (p<0.001) and glucose metabolism impairment (p<0.06–0.01). In both genders fatigue was increased by age (p<0.001) and BMI (p<0.05–0.01), but augmented by low levels of HDL-cholesterol in men only (p<0.05). Conclusions: Besides depending on mechanical overload and age, low muscle power output in obese individuals was independently associated also with metabolic abnormalities related to impaired glucose homeostasis. Fatigue and performance, although similarly influenced by age and body mass excess, are affected by different metabolic factors.

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Authors and Affiliations

  1. Istituito di Bioimmagini e Fisiologia Molecolare, Consiglio Nazionale delle Ricerche, Via Cervi 93, I-20090, Segrate, Milano, Italy

    C. L. Lafortuna MD

  2. Istituto di Tecnologie Biomediche, Consiglio Nazionale delle Ricerche, Segrate, MI, Italy

    F. Prinelli & F. Adorni

  3. Dipartimento di Scienze per gli Alimenti, la Nutrizione e l’Ambiente, Università degli Studi di Milano, Milano, Italy

    F. Prinelli

  4. Istituto Auxologico Italiano, IRCCS, Laboratorio Sperimentale di Ricerche Auxo-endocrinologiche, Milano, Italy

    F. Agosti, A. De Col & A. Sartorio

  5. III Divisione di Malattie Metaboliche, Milano and Piancavallo, VB, Italy

    A. Sartorio

Authors
  1. C. L. Lafortuna MD
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  2. F. Prinelli
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  3. F. Adorni
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  4. F. Agosti
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  5. A. De Col
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  6. A. Sartorio
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Correspondence to C. L. Lafortuna MD.

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Lafortuna, C.L., Prinelli, F., Adorni, F. et al. Effect of mechanical and metabolic factors on motor function and fatigue in obese men and women: A cross-sectional study. J Endocrinol Invest 36, 1062–1068 (2013). https://doi.org/10.3275/9064

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