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Caveolin-1 and polymerase I and transcript release factor: New players in insulin-like growth factor-I receptor signaling

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Abstract

Caveolae are plasma membrane regions enriched in Caveolin proteins which regulate vesicular transport, endocytosis, and cell signaling. IGF-I receptor (IGF-IR) localizes in caveolae and tyrosine phosphorylates Caveolin-1 (Cav-1), the most represented caveolar protein. Cav-1 participates to IGF-IR internalization and signaling directly interacting with IGF-IR and its substrates. Recently, polymerase I and transcript release factor (PTRF) or Cavin-1, has been identified in the caveolar backbone. PTRF does not play a Cav-1 ancillary role and emerging data support a direct role of PTRF in IGF-IR signaling. PTRF and Cav-1 can bind IGF-IR and regulate IGF-IR internalization and plasma membrane replacement, mechanisms frequently deregulated in cancer cells. Although the exact roles of Cav-1 and IGF-IR in human cancer continue to be a matter of some debate, there is a strong evidence for an association between Cav-1 and IGF-IR in cancer development. With the discovery of IGF-IR interaction with PTRF in caveolae, new insight emerged to understand the growing functions of these domains in IGF-I action.

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Authors and Affiliations

  1. Department of Internal Medicine (DiMI), University of Genoa, Viale Benedetto XV/6, Genoa, Italy

    M. Hamoudane, S. Maffioli, R. Cordera, D. Maggi MD, PhD & B. Salani

  2. Faculty of Science and Techniques of Tangier, University of Abdelmalek Essaãdi, Tangier, Moroc

    M. Hamoudane

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  1. M. Hamoudane
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  2. S. Maffioli
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  3. R. Cordera
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  4. D. Maggi MD, PhD
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  5. B. Salani
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Correspondence to D. Maggi MD, PhD.

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M.H. and S. Maffioli contributed equally to this work.

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Hamoudane, M., Maffioli, S., Cordera, R. et al. Caveolin-1 and polymerase I and transcript release factor: New players in insulin-like growth factor-I receptor signaling. J Endocrinol Invest 36, 204–208 (2013). https://doi.org/10.3275/8848

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