Advertisement

Journal of Endocrinological Investigation

, Volume 36, Issue 1, pp 50–54 | Cite as

Possible efficacy of Lavender and Tea tree oils in the treatment of young women affected by mild idiopathic hirsutism

  • G. Tirabassi
  • L. Giovannini
  • F. Paggi
  • G. Panin
  • F. Panin
  • R. Papa
  • M. Boscaro
  • G. Balercia
Original Articles

Abstract

Background: Hirsutism is defined as the presence of excessive terminal hair in androgen-dependent areas of a woman’s body. Regarding this it has been suggested that Lavender and Tea tree oils may have antiandrogenic activities. Aim: To evaluate therapy based on Lavender and Tea tree oils in women suffering from mild idiopathic hirsutism (IH). Subjects and methods: A prospective, open-label, placebo-controlled, randomized study was performed: women affected by mild IH were randomly assigned to receive oil spray containing Lavender and Tea tree oils (group T) (no.=12) or placebo (group P) (no.=12) twice a day for 3 months in areas affected by hirsutism. Evaluation of hirsutism was carried out at baseline and after 3 months by Ferriman-Gallwey score and by measuring hair diameter taken from some body areas. A hematological and hormonal evaluation was carried out at baseline and after 3 months. Results: No significant variations were found in any of the hormones studied in groups T and P between baseline and after 3 months. A statistically significant decrease of hirsutism total score and of hair diameter was found in group T, while no statistically significant difference in these two parameters was observed in group P; in group T percentual reduction of hair diameter was significantly greater than in group P. Conclusions: Lavender and Tea tree oils applied locally on skin could be effective in reducing mild IH; this treatment could represent a safe, economic and practical instrument in the cure of this disease.

Key-words

Androgens hirsutism plant oils treatment women 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Azziz R, Carmina E, Sawaya ME. Idiopathic hirsutism. Endocr Rev 2000, 21: 347–62.PubMedGoogle Scholar
  2. 2.
    Sachdeva S. Hirsutism: evaluation and treatment. Indian J Dermatol 2010, 55: 3–7.PubMedCentralPubMedCrossRefGoogle Scholar
  3. 3.
    Arnaldi G, Tirabassi G, Papa R, et al. Human corticotropin releasing hormone test performance in the differential diagnosis between Cushing’s disease and pseudo-Cushing state is enhanced by combined ACTH and cortisol analysis. Eur J Endocrinol 2009, 160: 891–8.PubMedCrossRefGoogle Scholar
  4. 4.
    Tirabassi G, Faloia E, Papa R, Furlani G, Boscaro M, Arnaldi G. Use of the desmopressin test in the differential diagnosis of pseudo-Cushing state from Cushing’s disease. J Clin Endocrinol Metab 2010, 95: 1115–22.PubMedCrossRefGoogle Scholar
  5. 5.
    Tirabassi G, Papa R, Faloia E, Boscaro M, Arnaldi G. Corticotrophinreleasing hormone and desmopressin tests in the differential diagnosis between Cushing’s disease and pseudo-Cushing state: a comparative study. Clin Endocrinol (Oxf) 2011, 75: 666–72.CrossRefGoogle Scholar
  6. 6.
    Arnaldi G, Mancini T, Tirabassi G, Trementino L, Boscaro M. Advances in the epidemiology, pathogenesis, and management of Cushing’s syndrome complications. J Endocrinol Invest 2012, 35: 434–48.PubMedGoogle Scholar
  7. 7.
    Escobar-Morreale HF, Sanchón R, San Millán JL. A prospective study of the prevalence of nonclassical congenital adrenal hyperplasia among women presenting with hyperandrogenic symptoms and signs. J Clin Endocrinol Metab 2008, 93: 527–33.PubMedCrossRefGoogle Scholar
  8. 8.
    Escobar-Morreale HF. Diagnosis and management of hirsutism. Ann N Y Acad Sci 2010, 1205: 166–74.PubMedCrossRefGoogle Scholar
  9. 9.
    Escobar-Morreale HF, Serrano-Gotarredona J, García-Robles R, Sancho J, Varela C. Mild adrenal and ovarian steroidogenic abnormalities in hirsute women without hyperandrogenemia: does idiopathic hirsutism exist? Metabolism 1997, 46: 902–7.PubMedCrossRefGoogle Scholar
  10. 10.
    Henley DV, Korach KS. Physiological effects and mechanisms of action of endocrine disrupting chemicals that alter estrogen signaling. Hormones (Athens) 2010, 9: 191–205.CrossRefGoogle Scholar
  11. 11.
    Moon T, Wilkinson JM, Cavanagh HM. Antiparasitic activity of two Lavandula essential oils against Giardia duodenalis, Trichomonas vaginalis and Hexamita inflata. Parasitol Res 2006, 99: 722–8.PubMedCrossRefGoogle Scholar
  12. 12.
    Inouye S, Takizawa T, Yamaguchi H. Antibacterial activity of essential oils and their major constituents against respiratory tract pathogens by gaseous contact. J Antimicrob Chemother 2001, 47: 565–73.PubMedCrossRefGoogle Scholar
  13. 13.
    Henley DV, Lipson N, Korach KS, Bloch CA. Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med 2007, 356: 479–85.PubMedCrossRefGoogle Scholar
  14. 14.
    Martin KA, Chang RJ, Ehrmann DA, et al. Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2008, 93: 1105–20.PubMedCrossRefGoogle Scholar
  15. 15.
    Javidnia K, Dastgheib L, Mohammadi Samani S, Nasiri A. Antihirsutism activity of Fennel (fruits of Foeniculum vulgare) extract. A double-blind placebo controlled study. Phytomedicine 2003, 10: 455–8.PubMedCrossRefGoogle Scholar
  16. 16.
    Hatch R, Rosenfield RL, Kim MH, Tredway D. Hirsutism: implications, etiology, and management. Am J Obstet Gynecol 1981, 140: 815–30.PubMedGoogle Scholar
  17. 17.
    Harrison S, Somani N, Bergfeld WF. Update on the management of hirsutism. Cleve Clin J Med 2010, 77: 388–98.PubMedCrossRefGoogle Scholar
  18. 18.
    Huang L, Abuhamdah S, Howes MJ, et al. Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels. J Pharm Pharmacol 200, 60: 1515–22.Google Scholar
  19. 19.
    Cavanagh HM, Wilkinson JM. Biological activities of lavender essential oil. Phytother Res 2002, 16: 301–8.PubMedCrossRefGoogle Scholar
  20. 20.
    Peter KV. Handbook of Herbs and Spices Volume 2. Abington Hall, Abington: Woodhead Publishing Ltd. 2004, 11.CrossRefGoogle Scholar
  21. 21.
    Carson CF, Hammer KA, Riley TV. Melaleuca alternifolia (Tea Tree) oil: a review of antimicrobial and other medicinal properties. Clin Microbiol Rev 2006, 19: 50–62.PubMedCentralPubMedCrossRefGoogle Scholar
  22. 22.
    Hunter MH, Carek PJ. Evaluation and treatment of women with hirsutism. Am Fam Physician 2003, 67: 2565–72.PubMedGoogle Scholar
  23. 23.
    Randall VA. Androgens and human hair growth. Clin Endocrinol (Oxf) 1994, 40: 439–57.CrossRefGoogle Scholar
  24. 24.
    Ebling FJ. Hair follicles and associated glands as androgen targets. Clin Endocrinol Metab 1986, 15: 319–39.PubMedCrossRefGoogle Scholar
  25. 25.
    Jenkins JS, Ash S. The metabolism of testosterone by human skin in disorders of hair growth. J Endocrinol 1973, 59: 345–51.PubMedCrossRefGoogle Scholar
  26. 26.
    Escobar-Morreale HF, Carmina E, Dewailly D, et al. Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society. Hum Reprod Update 2012, 18: 146–70.PubMedCrossRefGoogle Scholar

Copyright information

© Italian Society of Endocrinology (SIE) 2013

Authors and Affiliations

  • G. Tirabassi
    • 1
  • L. Giovannini
    • 1
  • F. Paggi
    • 1
  • G. Panin
    • 2
  • F. Panin
    • 2
  • R. Papa
    • 3
  • M. Boscaro
    • 1
  • G. Balercia
    • 1
  1. 1.Division of Endocrinology, Department of Clinical and Molecular SciencesUmberto I Hospital, Polytechnic University of MarcheAnconaItaly
  2. 2.Hulka S.r.l.RovigoItaly
  3. 3.Centre of Socio-economic Gerontological Research, Scientific-Technological AreaINRCA (Italian National Institute on Aging)AnconaItaly

Personalised recommendations