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12(S)-hydroxyeicosatetraenoic acid levels link to coronary artery disease in Type 2 diabetic patients

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Abstract

Background: 12(S)-Hydroxyeicosatetraenoic acid (12(S)-HETE) is a metabolite of arachidonic acid. 12(S)-HETE is involved in the pathogenesis of atherosclerosis and diabetes. However, the correlation between 12(S)-HETE and coronary artery disease (CAD) in the diabetic patient is unclear. Aims: The study investigated the relationship between 12(S)-HETE and CAD in Type 2 diabetes (T2D). Methods: Plasma 12(S)-HETE levels were detected by enzyme-linked immunosorbent assay in 103 healthy controls (control), 109 diabetic patients without CAD (diabetic), and 152 diabetic patients with CAD (diabetic-CAD). Results: 12(S)-HETE levels were higher in both diabetic and diabetic-CAD groups compared to control and in the diabetic-CAD group compared to the diabetic group. In the multiple linear stepwise regression analysis, 12(S)-HETE levels correlated independently with CAD, systolic blood pressure, and glycated hemoglobin. Conclusions: These results indicate that 12(S)-HETE levels are increased in diabetic patients with CAD, suggesting a role for atherosclerosis in T2D.

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Authors and Affiliations

  1. Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China

    H. J. Zhang, H. Y. Kuang, X. Y. Jiang & H. L. Liu

  2. School of Public Health, Harbin Medical University, 194 Xuefu Road, Harbin, China

    C. H. Sun PhD, H. Sui & R. Qi

  3. Zunhua People’s Hospital, Zunhua, China

    W. F. Hua & Z. J. Liu

  4. People’s Liberation Army 93383 Hospital, Mudanjiang, China

    H. Zhou

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  1. H. J. Zhang
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Correspondence to C. H. Sun PhD.

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Zhang, H.J., Sun, C.H., Kuang, H.Y. et al. 12(S)-hydroxyeicosatetraenoic acid levels link to coronary artery disease in Type 2 diabetic patients. J Endocrinol Invest 36, 385–389 (2013). https://doi.org/10.3275/8654

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  • DOI: https://doi.org/10.3275/8654

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