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Effect of diet-induced weight loss on inflammatory cytokines in obese women

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Abstract

Background: Obesity is associated with low-grade systemic inflammation which has been linked to the increased risk of cardiovascular disease and Type 2 diabetes in obese patients. Aim: To evaluate changes in pro/anti-inflammatory adipocytokines and metabolic profile after moderate diet-induced weight loss. Subjects and methods: Twenty-nine pre-menopausal obese women (body mass index ≥30 kg/m2) aged 21 to 54 years without diabetes, hypertension, or hyperlipidemia, were enrolled in this study. We measured anthropometric parameters, lipid and glucose profiles, interleukin (IL)-6, IL-10, and IL-18 in obese women, who then entered a medically supervised program aimed at reducing body weight by 10% or more. Obese women restricted their caloric intake (by 500–1000 kcal/day) and consumed 50 g/day of a fiber supplement (Slim Last Powder) for 12 weeks. Results: By completing the dietary intervention program, weight (Δ=−10.0%, p<0.0001), body mass index, waist circumference, triceps skinfold thickness, total cholesterol, triglyceride, and fasting plasma glucose significantly decreased, while HDL-cholesterol significantly increased. While plasma levels of IL-6 and IL-18 decreased by 27% after 12 weeks, no significant change was observed in circulating levels of IL-10. Conclusion: Our study suggests that an improved body composition induced by restriction of energy intake is associated with favorable serum concentrations of IL-6 and IL-18 in obese women. However, the anti-inflammatory IL-10 is not affected by a moderate weight decrease.

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Authors and Affiliations

  1. Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Poursina Ave., Qods St., 141556446, Tehran, Iran

    N. Tajik, S. A. Keshavarz, M. Djalali PhD, DsC, H. Hale Sadrzadeh-Yeganeh, M. Chamary, Z. Ahmadivand & M. H. Javanbakht

  2. Obesity and Food Group Set, Endocrine and Metabolism Sciences Research Institute, Tehran, Iran

    N. Tajik & T. Yazdani

  3. Students’ Scientific Research Center (SSRC), Tehran, Iran

    F. Masoudkabir

  4. Epidemiology and Biostatistics Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    M. R. Eshraghian

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  1. N. Tajik
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  2. S. A. Keshavarz
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  3. F. Masoudkabir
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  4. M. Djalali PhD, DsC
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  6. M. R. Eshraghian
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  7. M. Chamary
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  8. Z. Ahmadivand
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  10. M. H. Javanbakht
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Correspondence to M. Djalali PhD, DsC.

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Tajik, N., Keshavarz, S.A., Masoudkabir, F. et al. Effect of diet-induced weight loss on inflammatory cytokines in obese women. J Endocrinol Invest 36, 211–215 (2013). https://doi.org/10.3275/8465

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