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Vitamin D supplementation is required to normalize serum level of 25OH-vitamin D in older adults: An observational study of 974 hip fracture inpatients

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Abstract

Background: Vitamin D deficiency is highly prevalent in older adults in all continents. In this study we assessed the vitamin D status of hip fracture subjects across different hospitals in a real word situation using the data from a multicenter cohort study on outcomes in orthogeriatric units. Methods: We performed a prospective cohort study on 974 consecutive patients 75 yr or older admitted with fragility hip fracture over a 12 months period at 4 general hospitals of different districts in Emilia Romagna Region, Italy. Data collected included comorbidity, cognitive impairment, pre-fracture functional status, walking ability, living arrangement along with the use of antiosteoporotic drugs, serum intact PTH and serum 25-hydroxyvitamin D [25(OH)D]. Results: Mean 25(OH)D serum levels were 12.2±9.4 ng/ml and 84.2% of patients had levels below recommended values. Male had a higher probability to have values within the reference range [odds ratio (OR): 1.74 (1.13−2.67); p=0.012] while living in nursing resulted negatively related even if only close to statistical significance [OR: 0.24 (0.06−1.02); p=0.051]. Vitamin D supplementation appeared to be the strongest factor associated with adequate level of vitamin D levels [OR: 4.50 (2.57−7.88); p<0.001). Conclusion: This study confirmed the very high rate of severe vitamin D deficiency in Italian subjects admitted with hip fracture. Our study also showed that supplementation of vitamin D is the strongest determinant influencing serum 25(OH)D level of older persons with hip fracture and these results should be taken into account when planning treatment in older persons.

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Authors and Affiliations

  1. Geriatric Unit, Geriatric-Rehabilitation Department, University Hospital of Parma, Parma, Italy

    F. Lauretani & A. Giordano

  2. Orthogeriatric Unit, Department of Internal medicine, ageing and nephrology, University Hospital Policlinico S. Orsola Malpighi, Bologna, Italy

    C. Frondini & E. Martini

  3. Geriatrics Unit, Department of Neuromotor Physiology, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy

    M. L. Davoli, F. Pellicciotti & G. Pioli

  4. Orthogeriatric Unit, S. Anna Hospital, Ferrara, Italy

    A. Zagatti & A. Zurlo

Authors
  1. F. Lauretani
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  2. C. Frondini
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  3. M. L. Davoli
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  4. E. Martini
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  5. F. Pellicciotti
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  6. A. Zagatti
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  7. A. Giordano
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  8. A. Zurlo
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  9. G. Pioli
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Correspondence to G. Pioli.

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Lauretani, F., Frondini, C., Davoli, M.L. et al. Vitamin D supplementation is required to normalize serum level of 25OH-vitamin D in older adults: An observational study of 974 hip fracture inpatients. J Endocrinol Invest 35, 921–924 (2012). https://doi.org/10.3275/8457

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