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Regional muscle glucose uptake remains elevated one week after cessation of resistance training independent of altered insulin sensitivity response in older adults with Type 2 diabetes

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Abstract

Background: Aging is associated with a decline in skeletal muscle size. Muscle is critical both for mobility and glucose disposal. While resistance exercise (RE) increases muscle mass and function in the elderly, its role in improving glucose utilization is less clear. Aims: To investigate whether muscle size was linked with insulin sensitivity (IS) in elders with diabetes following RE and if regional muscle glucose uptake differed from systemic glucose utilization. Methods: Seven (68.4±5.9 yr) adults with diabetes participated. After 16 weeks of RE, within 24 h (post 1) and after 1 week of no exercise (post 2), lean tissue cross-sectional area (CSA) and IS via glucose infusion rate (GIR) were assessed along with a standardized 18-F fluorodeoxyglucose (FDG)-positron emission tomography uptake value (SUV). Results: CSA increased between pre-test (108.5±35.3 cm2) and post 1 (116.8±40.9 cm2), p=0.02 and did not differ at post 2 (116.0±39.3 cm2). GIR during the 40 mU/m2/min insulin clamp differed between pretest (22.0±15.8 mg/kg/min) and post 1 (67.9±72.8 mg/kg/min), and post 1 and post 2 (25.0±27.2 mg/kg/min) but not between pre-test and post 2. GIR results during the 200 mU/m2/min insulin clamps also differed between pre-test and post 1, and post 1 and post 2 but not between pre-test and post 2. FDG-SUV increased between pre-test (1.1 ±0.2) and post 1 (1.4±0.3), and remained stable between post 1 and post 2 (1.4±0.4). Conclusion: RE that increased muscle size and FDG-SUV improved IS 24 h but not 1 week after exercise training.

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References

  1. DeFronzo RA, Gunnarsson R, Björkman O, Olsson M, Wahren J. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest 1985, 76: 149–55.

    PubMed Central  PubMed  Google Scholar 

  2. Canadian Diabetes Association Clinical Practice Guidelines Expert Committee: Physical activity and diabetes. Can J Diabetes 2003, 27(Suppl 2): S24–6.

    Google Scholar 

  3. American Diabetes Association. Standards of medical care in dia-betes—2008. Diabetes Care 2008, 31(Suppl 1): S12–54.

    Google Scholar 

  4. Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C, White RD. Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes Care 2006, 29: 1433–8.

    PubMed  Google Scholar 

  5. Karakelides H, Nair KS. Sarcopenia of aging and its metabolic impact. Curr Top Dev Biol 2005, 68: 123–48.

    PubMed  Google Scholar 

  6. Gordon BA, Benson AC, Bird SR, Fraser SF. Resistance training improves metabolic health in type 2 diabetes: a systematic review. Diabetes Res Clin Pract 2009, 83: 157–75.

    PubMed  Google Scholar 

  7. Bobeuf F, Labonté M, Khalil A, Dionne IJ. Effects of resistance training combined with antioxidant supplementation on fat-free mass and insulin sensitivity in healthy elderly subjects. Diabetes Res Clin Pract 2010, 87: e1–3.

    PubMed  Google Scholar 

  8. Goulet ED, Mélançon MO, Dionne IJ, Aubertin-Leheudre M. No sustained effect of aerobic or resistance training on insulin sensitivity in nonobese, healthy older women. J Aging Phys Act 2005, 13: 314–26.

    PubMed  Google Scholar 

  9. Marcus RL, Lastayo PC, Dibble LE, Hill L, McClain DA. Increased strength and physical performance with eccentric training in women with impaired glucose tolerance: a pilot study. J Womens Health (Larchmt) 2009, 18: 253–60.

    Google Scholar 

  10. Ferrara CM, Goldberg AP, Ortmeyer HK, Ryan AS. Effects of aerobic and resistive exercise training on glucose disposal and skeletal muscle metabolism in older men. J Gerontol A Biol Sci Med Sci 2006, 61: 480–7.

    PubMed  Google Scholar 

  11. Goulet ED, Mélançon MO, Aubertin-Leheudre M, Dionne IJ. Aerobic training improves insulin sensitivity 72–120 h after the last exercise session in younger but not in older women. Eur J Appl Physiol 2005, 95: 146–52.

    PubMed  Google Scholar 

  12. Yki-Järvinen H, Koivisto VA. Effects of body composition on insulin sensitivity. Diabetes 1983, 32: 965–9.

    PubMed  Google Scholar 

  13. Holten MK, Zacho M, Gaster M, Juel C, Wojtaszewski JF, Dela F. Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. Diabetes 2004, 53: 294–305.

    PubMed  Google Scholar 

  14. Ishii T, Yamakita T, Sato T, Tanaka S, Fujii S. Resistance training improves insulin sensitivity in NIDDM subjects without altering maximal oxygen uptake. Diabetes Care 1998, 21: 1353–5.

    PubMed  Google Scholar 

  15. Dibble LE, Hale TF, Marcus RL, Droge J, Gerber JP, LaStayo PC. High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson’s disease. Mov Disord 2006, 21: 1444–52.

    PubMed  Google Scholar 

  16. LaStayo PC, Ewy GA, Pierotti DD, Johns RK, Lindstedt S. The positive effects of negative work: increased muscle strength and decreased fall risk in a frail elderly population. J Gerontol A Biol Sci Med Sci 2003, 58: M419–24.

    PubMed  Google Scholar 

  17. Marcus RL, Smith S, Morrell G, et al. Comparison of combined aerobic and high-force eccentric resistance exercise with aerobic exercise only for people with type 2 diabetes mellitus. Phys Ther 2008, 88: 1345–54.

    PubMed Central  PubMed  Google Scholar 

  18. Meyer K, Steiner R, Lastayo P, et al. Eccentric exercise in coronary patients: central hemodynamic and metabolic responses. Med Sci Sports Exerc 2003, 35: 1076–82.

    PubMed  Google Scholar 

  19. Elder CP, Apple DF, Bickel CS, Meyer RA, Dudley GA. Intramuscular fat and glucose tolerance after spinal cord injury—a cross-sectional study. Spinal Cord 2004, 42: 711–6.

    PubMed  Google Scholar 

  20. Gorgey AS, Dudley GA. Skeletal muscle atrophy and increased intramuscular fat after incomplete spinal cord injury. Spinal Cord 2007, 45: 304–9.

    PubMed  Google Scholar 

  21. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979, 237: E214–23.

    PubMed  Google Scholar 

  22. DeGrado TR, Turkington TG, Williams JJ, Stearns CW, Hoffman JM, Coleman RE. Performance characteristics of a whole-body PET scanner. J Nucl Med 1994, 35: 1398–406.

    PubMed  Google Scholar 

  23. Bergstom J. Muscle electrolytes in man. Scand J Clin Lab Invest 1962, 68 (Suppl): 48–52.

    Google Scholar 

  24. Kuk JL, Kilpatrick K, Davidson LE, Hudson R, Ross R. Whole-body skeletal muscle mass is not related to glucose tolerance or insulin sensitivity in overweight and obese men and women. Appl Physiol Nutr Metab 2008, 33: 769–74.

    PubMed  Google Scholar 

  25. Goodpaster BH, Thaete FL, Simoneau JA, Kelley DE. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 1997, 46: 1579–85.

    PubMed  Google Scholar 

  26. Heath GW, Gavin JR 3rd, Hinderliter JM, Hagberg JM, Bloomfield SA, Holloszy JO. Effects of exercise and lack of exercise on glucose tolerance and insulin sensitivity. J Appl Physiol 1983, 55: 512–7.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Physical Therapy, University of Utah, 520 Wakara Way, Salt Lake City, UT, 84108, USA

    R. L. Marcus PT, PhD, O. Addison & P. C. LaStayo

  2. Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine, Salt Lake City, Utah, USA

    R. Hungerford, A. R. Wende, E. D. Abel & D. A. McClain

  3. Salt Lake Veterans Affairs Medical Center, University of Utah School of Medicine, Salt Lake City, Utah, USA

    D. A. McClain

  4. Department of Radiology, University of Utah School of Medicine, Salt Lake City, Utah, USA

    J. M. Hoffman

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  1. R. L. Marcus PT, PhD
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  2. O. Addison
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  3. P. C. LaStayo
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  4. R. Hungerford
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  8. D. A. McClain
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Correspondence to R. L. Marcus PT, PhD.

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Marcus, R.L., Addison, O., LaStayo, P.C. et al. Regional muscle glucose uptake remains elevated one week after cessation of resistance training independent of altered insulin sensitivity response in older adults with Type 2 diabetes. J Endocrinol Invest 36, 111–117 (2013). https://doi.org/10.3275/8333

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  • DOI: https://doi.org/10.3275/8333

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