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The effect of three-month pre-season preparatory period and short-term exercise on plasma leptin, adiponectin, visfatin, and ghrelin levels in young female handball and basketball players

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Abstract

Objective: The aim of the study was to assess the effect of a 3-month pre-season preparatory period and short-term moderate aerobic exercise and intensive fitness and speed exercise on adipokine and ghrelin levels in young female handball and basketball players. Materials and methods: Fifty healthy young female professional basketball and handball players were enrolled into the study before the opening of the season (after a 2-month holiday with no training or dietary restrictions). Serum estradiol and plasma leptin, adiponectin, visfatin, and ghrelin levels were determined at the beginning and the end of a 3-month period of moderate aerobic training. Plasma adipokines and ghrelin levels were additionally assessed after 2 h of moderate aerobic exercise or after intensive fitness and speed exercise training. Results: Long-term moderate aerobic exercise was followed by a significant decrease in plasma ghrelin and leptin levels (921 ±300 vs 575±572 pg/ml. p<0.001 and 16.4±15.6 vs 11.8±16.3 ng/ml, p<0.01, respectively); plasma adiponectin and visfatin remained unchanged. No changes were observed in plasma ghrelin and leptin levels after short-term moderate aerobic exercise or after intensive fitness and speed exercise. Plasma visfatin concentration increased significantly after short-term moderate aerobic exercise (22.1 ±8.7 vs 27.6±9.0 ng/ml, p<0.001), whilst adiponectin increased after intensive fitness and speed exercise (16.7±7.8 vs 21.0±9.8 µg/ml, p<0.001). Conclusions: Regular moderate aerobic training in preparation for the match season is followed by a decline in circulating leptin and ghrelin levels even in athletes without body weight changes. Short-term intensive fitness and moderate aerobic exercise seem to modulate the production of different adipokines.

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References

  1. Olszanecka-Glinianowicz M, Zahorska-Markiewicz B. Obesity as inflammatory disease. Postepy Hig Med Dosw (Online) 2008, 27: 249–57.

    Google Scholar 

  2. Chudek J, Adamczak M, Nieszporek T, Wiecek A. The adipose tissue as an endocrine organ—a nephrologist’s perspective. Contrib Nephrol 2006, 151: 79–90.

    Google Scholar 

  3. Rodríguez-Rodríguez E, Perea JM, López-Sobaler AM, Ortega RM. Obesity, insulin resistance and increase in adipokines levels: importance of the diet and physical activity. Nutr Hosp 2009, 24: 415–21.

    PubMed  Google Scholar 

  4. Zahorska-Markiewicz B, Mizia-Stec K, Olszanecka-Glinianowicz M, Janowska J. Effect of weight reduction on serum ghrelin and TNFalpha concentrations in obese women. Eur J Intern Med 2004, 15: 172–5.

    Article  PubMed  Google Scholar 

  5. Feicht CB, Johnson TS, Martin BJ, Sparkes KE, Wagner WW Jr. Secondary amenorrhoea in athletes. Lancet 1978, 2: 1145–6.

    Article  PubMed  Google Scholar 

  6. Dale E, Gerlach DH, Wilhite AL. Menstrual dysfunction in distance runners. Obstet Gynecol 1979, 54: 47–53.

    Article  PubMed  Google Scholar 

  7. Glass AR, Deuster PA, Kyle SB, Yahiro JA, Vigersky RA, Schoomaker EB. Amenorrhea in Olympic marathon runners. Fertil Steril 1987, 48: 740–5.

    PubMed  Google Scholar 

  8. De Souza MJ, Miller BE, Loucks AB, et al. High frequency of luteal phase deficiency and anovulation in recreational women runners: blunted elevation in follicle-stimulating hormone observed during luteal-follicular transition. J Clin Endocrinol Metab 1998, 83: 4220–32.

    PubMed  Google Scholar 

  9. De Souza MJ, Williams NI. Physiological aspects and clinical squeal of energy deficiency and hypoestrogenism in exercising women. Hum Reprod Update 2004, 10: 433–48.

    Article  PubMed  Google Scholar 

  10. Hoch AZ, Stavrakos JE, Schimke JE. Prevalence of female athlete triad characteristics in a club triathlon team. Arch Phys Med Rehabil 2007, 88: 681–2.

    Article  PubMed  Google Scholar 

  11. McNeely MJ, Soules MR. The diagnosis of luteal phase deficiency: a critical review. Fertil Steril 1988, 50: 1–15.

    PubMed  Google Scholar 

  12. Nattiv A, Loucks AB, Manore MM, Sanborn CF, Sundgot-Borgen J, Warren MP; American College of Sports Medicine. American College of Sports Medicine position stand. The female athlete triad. Med Sci Sports Exerc 2007, 39: 1867–82.

    PubMed  Google Scholar 

  13. O’Donnell E, Harvey PJ, Goodman JM, De Souza MJ. Long-term estrogen deficiency lowers regional blood flow, resting systolic blood pressure, and heart rate in exercising premenopausal women. Am J Physiol Endocrinol Metab 2007, 292: E1401–9.

    Article  PubMed  Google Scholar 

  14. O’Donnell E, Harvey PJ, De Souza MJ. Relationships between vascular resistance and energy deficiency, nutritional status and oxidative stress in oestrogen deficient physically active women. Clin Endocrinol (Oxf) 2009, 70: 294–302.

    Article  Google Scholar 

  15. Gordon CM. Clinical practice. Functional hypothalamic amenorrhea. N Engl J Med 2010, 363: 365–71.

    Article  PubMed  Google Scholar 

  16. Benatti FB, Polacow VO, Ribeiro SML, et al. Swimming training down-regulates plasma leptin levels, but not adipose tissue ob m RNA expression. Braz J Med Biol Res 2008, 41: 866–71.

    Article  PubMed  Google Scholar 

  17. Haluzík M, Boudová L, Nedvídková J, et al. Lower serum leptin concentrations in rugby players in comparison with healthy non-sporting subjects—relationships to anthropometric and biochemical parameters. Eur J Appl Physiol Occup Physiol 1988, 79: 58–61.

    Article  Google Scholar 

  18. Miyazaki S, Izawa T, Ogasawara JE, et al. Effect of exercise training on adipocyte-size-dependent expression of leptin and adiponectin. Life Sci 2010, 86: 691–8.

    Article  PubMed  Google Scholar 

  19. Jürimäe J, Kums T, Jürimäe T. Plasma adiponectin concentration is associated with the average accelerometer daily steps counts in healthy elderly females. Eur J Appl Physiol 2010, 109: 823–8.

    Article  PubMed  Google Scholar 

  20. Jürimäe J, Purge P, Jürimäe T. Adiponectin and stress hormone responses to maximal sculling after volume-extended training season in elite rowers. Metabolism 2006, 55: 13–9.

    Article  PubMed  Google Scholar 

  21. O’Donnell E, De Souza MJ. Increased serum adiponectin concentrations in amenorrheic physically active women are associated with impaired bone health but not with estrogen exposure. Bone 2011, 48: 760–7.

    Article  PubMed  Google Scholar 

  22. Jürimäe J, Cicchella A, Jürimäe T, et al. Regular physical activity influences plasma ghrelin concentration in adolescent girls. Med Sci Sports Exerc 2007, 39: 1736–41.

    Article  PubMed  Google Scholar 

  23. De Souza MJ, Leidy HJ, O’Donnell E, Lasley B, Williams NI. Fasting ghrelin levels in physically active women: relationship with menstrual disturbances and metabolic hormones. J Clin Endocrinol Metab 2004, 89: 3536–42.

    Article  PubMed  Google Scholar 

  24. Holst B, Schwartz TW. Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation. Trends Pharmacol Sci 2004, 25: 113–7.

    Article  PubMed  Google Scholar 

  25. Jürimäe J, Rämson R, Mäestu J, et al. Plasma visfatin and ghrelin response to prolonged sculling in competitive male rowers. Med Sci Sports Exerc 2009, 41: 137–43.

    Article  PubMed  Google Scholar 

  26. Gruodytė R, Jürimäe J, Cicchella A, Stefanelli C, Passariello C, Jürimäe T. Adipocytokines and bone mineral density in adolescent female athletes. Acta Pediatr 2010, 99: 1879–984.

    Article  Google Scholar 

  27. Franks PW, Farooqi IS, Luan J, et al. Does physical activity energy expenditure explain the between-individual variation in plasma leptin concentrations after adjusting for differences in body composition? J Clin Endocrinol Metab 2003, 88: 3258–63.

    Article  PubMed  Google Scholar 

  28. Leidy HJ, Gardner JK, Frye BR, et al. Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women. J Clin Endocrinol Metab 2004, 89: 2659–64.

    Article  PubMed  Google Scholar 

  29. Haus JM, Solomon TP, Marchetti CM, et al. Decreased visfatin after exercise training correlates with improved glucose tolerance. Med Sci Sports Exerc 2009, 41: 1255–60.

    Article  PubMed  Google Scholar 

  30. Holm C. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem Soc Trans 2003, 31: 1120–4.

    Article  PubMed  Google Scholar 

  31. Grisouard J, Bouillet E, Timper K, et al. Both inflammatory and classical lipolytic pathways are involved in lipopolysaccharides-induced lipolysis in human adipocytes. Innate Immun 2012, 18: 25–34.

    Article  PubMed  Google Scholar 

  32. Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R. Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes. FEBS Lett 2001, 507: 142–6.

    Article  PubMed  Google Scholar 

  33. Ferguson MA, White LJ, McCoy S, Kim HW, Petty T, Wilsey J. Plasma adiponectin response to acute exercise in healthy subjects. Eur J Appl Physiol 2004, 91: 324–9.

    Article  PubMed  Google Scholar 

  34. Punyadeera C, Zorenc AH, Koopman R, et al. The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle. Eur J Endocrinol 2005, 152: 427–36.

    Article  PubMed  Google Scholar 

  35. Jürimäe J, Purge P, Jürimäe T. Adiponectin is altered after maximal exercise in highly trained male rowers. Eur J Appl Physiol 2005, 93: 502–5.

    Article  PubMed  Google Scholar 

  36. Ghanbari-Niaki A, Saghebjoo M, Soltani R, Kirwan JP. Plasma visfatin is increased after high-intensity exercise. Ann Nutr Metab 2010, 57: 3–8.

    Article  PubMed  Google Scholar 

  37. Schmidt A, Maier C, Schaller G, et al. Acute exercise has no effect on ghrelin plasma concentrations. Horm Metab Res 2004, 36: 174–7.

    Article  PubMed  Google Scholar 

  38. Zoladz JA, Konturek SJ, Duda K, et al. Effect of moderate incremental exercise, performed in fed and fasted state on cardio-respiratory variables and leptin and ghrelin concentrations in young healthy men. J Physiol Pharmacol 2005, 56: 63–85.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Physical Education and Sport, Medical University of Silesia, Katowice, Poland

    R. Plinta

  2. Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical University of Silesia, Katowice, Poland

    M. Olszanecka-Glinianowicz

  3. Woman’s Health Institute, Medical University of Silesia, ul. Medyków 12, 40-752, Katowice, Poland

    A. Drosdzol-Cop MD, PhD & V. Skrzypulec-Plinta

  4. Pathophysiology Unit, Department of Pathophysiology, Medical University of Silesia, Katowice, Poland

    J. Chudek

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  1. R. Plinta
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Correspondence to A. Drosdzol-Cop MD, PhD.

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Plinta, R., Olszanecka-Glinianowicz, M., Drosdzol-Cop, A. et al. The effect of three-month pre-season preparatory period and short-term exercise on plasma leptin, adiponectin, visfatin, and ghrelin levels in young female handball and basketball players. J Endocrinol Invest 35, 595–601 (2012). https://doi.org/10.3275/8014

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