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Insulin sensitivity in response to a single resistance exercise session in apparently healthy individuals

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Abstract

Background: Regular resistance exercise completed for a number of weeks has been shown to increase insulin sensitivity and reduce the risk of diabetes-related complications. However, the acute responses to resistance exercise have not been adequately investigated in relation to training frequency. Aim: To investigate the changes to insulin sensitivity in apparently healthy individuals following a single session of unaccustomed resistance exercise. Subjects and methods: Ten sedentary, apparently healthy individuals performed a baseline oral glucose tolerance test and maximal strength testing. Participants then performed a single session of moderate-high intensity resistance exercise which was followed by 4 consecutive days of oral glucose tolerance testing, for which participants replicated their initial diet. Mean estimated insulin sensitivity change scores from baseline values and their 95% confidence intervals were compared to the previously determined values for a clinically meaningful change. Results: Two participants were identified as having hyperinsulinemia and their data were therefore removed from the main analysis. There was a clinically meaningful increase in insulin response (mean >7237 pmol·I−1·120 min−1) on all days following the exercise session and a clinically meaningful increase in glucose response (mean >81 mmol·I−1·120 min−1) on only the 3rd day following exercise. These changes suggest a potentially adverse short-term effect. Additionally, the 2 individuals with hyperinsulinemia displayed more extreme results. Conclusion: These results suggest that insulin sensitivity may be impaired following a single session of unaccustomed resistance exercise for approximately 4 days in healthy untrained, older individuals. Further research is required for individuals with hyperinsulinemia.

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References

  1. DeFronzo RA. Pathogenesis of type 2 diabetes mellitus. Med Clin North Am 2004, 88: 787–835, ix.

    Article  PubMed  Google Scholar 

  2. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006, 444: 860–7.

    Article  PubMed  Google Scholar 

  3. Johnson RJ, Segal MS, Sautin Y, et al. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 2007, 86: 899–906.

    PubMed  Google Scholar 

  4. Nguyen S, Lustig RH. Just a spoonful of sugar helps the blood pressure go up. Expert Rev Cardiovasc Ther 2010, 8: 1497–9.

    Article  PubMed  Google Scholar 

  5. Snowling NJ, Hopkins WG. Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients: a meta-analysis. Diabetes Care 2006, 29: 2518–27.

    Article  PubMed  Google Scholar 

  6. Williams MA, Haskell WL, Ades PA, et al; American Heart Association Council on Clinical Cardiology; American Heart Association Council on Nutrition, Physical Activity, and Metabolism. Resistance exercise in individuals with and without cardiovascular disease: 2007 update: a scientific statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism. Circulation 2007, 116: 572–84.

    Article  PubMed  Google Scholar 

  7. Gordon BA, Benson AC, Bird SR, Fraser SF. Resistance training improves metabolic health in type 2 diabetes: a systematic review. Diabetes Res Clin Pract 2009, 83: 157–75.

    Article  PubMed  Google Scholar 

  8. Chapman J, Garvin AW, Ward A, Cartee GD. Unaltered insulin sensitivity after resistance exercise bout by postmenopausal women. Med Sci Sports Exerc 2002, 34: 936–41.

    Article  PubMed  Google Scholar 

  9. Howlett KF, Sakamoto K, Garnham A, Cameron-Smith D, Hargreaves M. Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle. Diabetes 2007, 56: 1608–14.

    Article  PubMed  Google Scholar 

  10. Luebbers PE, Potteiger JA, Warren BJ, Clore JN, Jennings C, Bond DS. Glucose uptake after resistance training of different intensities but of equal work volume. J Strength Cond Res 2008, 22: 1094–100.

    Article  PubMed  Google Scholar 

  11. Fenicchia LM, Kanaley JA, Azevedo JL Jr, et al. Influence of resistance exercise training on glucose control in women with type 2 diabetes. Metabolism 2004, 53: 284–9.

    Article  PubMed  Google Scholar 

  12. Fluckey JD, Hickey MS, Brambrink JK, Hart KK, Alexander K, Craig BW. Effects of resistance exercise on glucose tolerance in normal and glucose-intolerant subjects. J Appl Physiol 1994, 77: 1087–92.

    PubMed  Google Scholar 

  13. Koopman R, Manders RJ, Zorenc AH, et al. A single session of resistance exercise enhances insulin sensitivity for at least 24 h in healthy men. Eur J Appl Physiol 2005, 94: 180–7.

    Article  PubMed  Google Scholar 

  14. King DS, Feltmeyer TL, Baldus PJ, Sharp RL, Nespor J. Effects of eccentric exercise on insulin secretion and action in humans. J Appl Physiol 1993, 75: 2151–6.

    PubMed  Google Scholar 

  15. Trost SG, Owen N, Bauman AE, Sallis JF, Brown W. Correlates of adults’ participation in physical activity: review and update. Med Sci Sports Exerc 2002, 34: 1996–2001.

    Article  PubMed  Google Scholar 

  16. World Health Organization. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: A report of a WHO/IDF consultation. Geneva, Switzerland: WHO Document Production Services, 2006.

    Google Scholar 

  17. Craig CL, Marshall AL, Sjöström M, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003, 35: 1381–95.

    Article  PubMed  Google Scholar 

  18. Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ. A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care 2001, 24: 539–48.

    Article  PubMed  Google Scholar 

  19. Tabachnick BG, Fidell LS. Using multivariate statistics. 4th ed. Needham Heights, MA, USA: Allyn & Bacon, 2001.

    Google Scholar 

  20. Andersen E, Høstmark AT. Effect of a single bout of resistance exercise on postprandial glucose and insulin response the next day in healthy, strength-trained men. J Strength Cond Res 2007, 21: 487–91.

    PubMed  Google Scholar 

  21. Braith RW, Stewart KJ. Resistance exercise training: its role in the prevention of cardiovascular disease. Circulation 2006, 113: 2642–50.

    Article  PubMed  Google Scholar 

  22. Kirwan JP, del Aguila LF. Insulin signalling, exercise and cellular integrity. Biochem Soc Trans 2003, 31: 1281–5.

    Article  PubMed  Google Scholar 

  23. King DS, Baldus PJ, Sharp RL, Kesl LD, Feltmeyer TL, Riddle MS. Time course for exercise-induced alterations in insulin action and glucose tolerance in middle-aged people. J Appl Physiol 1995, 78: 17–22.

    PubMed  Google Scholar 

  24. Miller JP, Pratley RE, Goldberg AP, et al. Strength training increases insulin action in healthy 50- to 65-yr-old men. J Appl Physiol 1994, 77: 1122–7.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Discipline of Exercise Sciences, School of Medical Sciences & Health Innovations Research Institute, RMIT University, Bundoora, Victoria, Australia

    B. A. Gordon MAppSc, S. R. Bird & A. C. Benson

  2. Physiotherapy Department, Austin Hospital, Heidelberg, Australia

    B. A. Gordon MAppSc

  3. School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Australia

    S. F. Fraser

Authors
  1. B. A. Gordon MAppSc
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  2. S. F. Fraser
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  3. S. R. Bird
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  4. A. C. Benson
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Correspondence to B. A. Gordon MAppSc.

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Gordon, B.A., Fraser, S.F., Bird, S.R. et al. Insulin sensitivity in response to a single resistance exercise session in apparently healthy individuals. J Endocrinol Invest 35, 665–669 (2012). https://doi.org/10.3275/7972

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