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Acute and chronic hypothyroidism are associated with similar left ventricular diastolic dysfunction relative to the euthyroid state: Results of doppler echocardiographic comparisons

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Abstract

Background: How the duration of hypothyroidism affects left ventricular diastolic function is not well-characterized. Aim: We sought to compare left ventricular diastolic function in acutely vs chronically hypothyroid patients vs euthyroid controls, and within individuals while on vs off T4. Subjects and methods: We prospectively performed such comparisons measuring pulsed-wave and color M-mode Doppler echocardiographic variables: early or late mitral peak velocities (E wave or A wave, respectively), E wave/A wave ratio, E wave deceleration time, isovolumic relaxation time (IVRT), mitral flow propagation velocity (Vp), E wave/Vp ratio. Subjects comprised the acute HYPO group, 10 patients undergoing T4 withdrawal ≥6 months post-primary treatment for differentiated thyroid cancer (DTC); the chronic HYPO group, 23 treatment-naïve Hashimoto thyroiditis patients; and 21 healthy euthyroid controls. Subjects were adults aged ≤60 yr, predominantly female, with sinus rhythm; exclusion criteria were cardiovascular or thyroid disorder besides DTC (Hashimoto thyroiditis) in acute (chronic) HYPO patients or medication (besides thyroid hormone) affecting cardiac or thyroid function. Results: Mean IVRT was significantly delayed and mean Vp, significantly slowed in both HYPO groups vs controls (p<0.0005), but did not differ between HYPO groups. These variables also were significantly impaired (p<0.05) within individuals when off vs on T4 (no.=8 acute, 10 chronic HYPO patients). Both HYPO groups had elevated mean E wave/Vp ratios vs controls, but the elevation reached significance (p<0.05) only in the larger chronic HYPO group. Conclusions: Left ventricular diastolic dysfunction is largely similar in acutely or chronically hypothyroid patients off T4 vs healthy controls or the same patients on T4.

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Authors and Affiliations

  1. División de Endocrinología, Hospital Ramos Mejía, Yerbal 11 1H, 1405, Buenos Aires, Argentina

    A. Gauna MD, F. Viale & M. C. Silva Croome

  2. Division of Cardiology, Ramos Mejía Hospital, Buenos Aires, Argentina

    H. Messuti, G. Papadopulos & G. Benchuga

  3. Spencer-Fontayne Corporation, Jersey City, NJ, USA

    R. J. Marlowe

Authors
  1. A. Gauna MD
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  2. H. Messuti
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  3. G. Papadopulos
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  4. G. Benchuga
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  5. F. Viale
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  6. R. J. Marlowe
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  7. M. C. Silva Croome
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Corresponding author

Correspondence to A. Gauna MD.

Additional information

An abstract of this work was presented at the 13th International Thyroid Congress, Buenos Aires, Argentina, October 30–November 4, 2005.

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Gauna, A., Messuti, H., Papadopulos, G. et al. Acute and chronic hypothyroidism are associated with similar left ventricular diastolic dysfunction relative to the euthyroid state: Results of doppler echocardiographic comparisons. J Endocrinol Invest 34, e281–e286 (2011). https://doi.org/10.3275/7740

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  • DOI: https://doi.org/10.3275/7740

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