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Hip circumference is associated with high density lipoprotein cholesterol response following statin therapy in hypertensive subjects

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Abstract

Aim: This report investigated the relationship between anthropometric measurements of body fat distribution and lipid response to statins in hypercholesterolemic hypertensive patients. Methods: We prospectively examined 129 subjects who used either simvastatin 20 mg/day (no.=83) or atorvastatin 10 mg/day (no.=46) for 3 months. Anthropometry included evaluation of body mass index, waist and hip circumferences, and waist-to-hip-ratio. Results: Significant decreases in LDL (p<0.001), total cholesterol (p<0.001), and triglycerides (p=0.04) levels were detected after 3 months of therapy in the whole sample. At baseline, only an inverse correlation between waist circumference and HDL-cholesterol levels was detected (r=−0.18; p=0.04). Conversely, a direct relationship between hip circumference and HDL-cholesterol response to statins was found in the whole sample (r=0.24; p=0.006), while no other anthropometric measurement displayed significant correlation with lipid changes. The association between HDL-cholesterol response and hip circumference was further confirmed by stepwise regression analysis adjusted for baseline HDL-cholesterol levels, metabolic syndrome, body mass index, and waist circumference. Conclusions: Hip circumference, a surrogate marker of peripheral adiposity, is associated with HDL-cholesterol changes following statin therapy in hypertensive patients.

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Authors and Affiliations

  1. Department of Internal Medicine, School of Medicine, University of Campinas, Campinas, Brazil

    J. A. Pio-Magalhães, M. C. Ferreira-Sae, F. A. Souza, A. M. Grespan-Magossi, R. Schreiber, L. A. Velloso, B. Geloneze, K. G. Franchini & W. Nadruz Jr MD, PhD

Authors
  1. J. A. Pio-Magalhães
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  2. M. C. Ferreira-Sae
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  3. F. A. Souza
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  4. A. M. Grespan-Magossi
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  5. R. Schreiber
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  6. L. A. Velloso
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  7. B. Geloneze
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  8. K. G. Franchini
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  9. W. Nadruz Jr MD, PhD
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Corresponding author

Correspondence to W. Nadruz Jr MD, PhD.

Additional information

J.A. Pio-Magalhães, M.C. Ferreira-Sae contributed equally to this study.

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Pio-Magalhães, J.A., Ferreira-Sae, M.C., Souza, F.A. et al. Hip circumference is associated with high density lipoprotein cholesterol response following statin therapy in hypertensive subjects. J Endocrinol Invest 34, 680–684 (2011). https://doi.org/10.3275/7725

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