Journal of NeuroVirology

, Volume 16, Issue 5, pp 377–383

Association between apolipoprotein E4 genotype and human immunodeficiency virus-associated dementia in younger adults starting antiretroviral therapy in South Africa

  • John A Joska
  • Marc Combrinck
  • Victor G Valcour
  • Jacqueline Hoare
  • Felicity Leisegang
  • Anna Cecilia Mahne
  • Landon Myer
  • Dan J Stein


It is not known whether the apolipoprotein E (ApoE) ε4 allelic variant is associated with human immunodeficiency virus (HIV)-associated dementia (HAD) in a South African population, where HIV clade C is predominant. ApoE genotyping was performed on 144 participants in a larger study of HIV-associated neurocognitive disorders (HAND). There was a lower frequency of the ε2 and ε3 alleles in the HIV-positive group, compared to a group of 300 community-based newborn infants. There were no differences in ApoE genotype across different categories of HAND. The ε4 allelic variant was less common in individuals with HAD than in those without HAD. These findings suggest that the ε4 allelic variant in HIV-positive individuals is not associated with the development of HAD in Southern Africa.


AIDS dementia complex amnestic disorders apolipoprotein E cognitive disorders delirium dementia 


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Copyright information

© Journal of NeuroVirology, Inc. 2010

Authors and Affiliations

  • John A Joska
    • 1
  • Marc Combrinck
    • 2
  • Victor G Valcour
    • 3
    • 4
  • Jacqueline Hoare
    • 1
  • Felicity Leisegang
    • 5
  • Anna Cecilia Mahne
    • 2
  • Landon Myer
    • 6
    • 7
  • Dan J Stein
    • 1
  1. 1.Department of Psychiatry and Mental HealthUniversity of Cape Town, J-block, Groote Schuur HospitalObservatory
  2. 2.Department of MedicineUniversity of Cape TownSouth Africa
  3. 3.Memory and Aging CenterUniversity of CaliforniaSan FranciscoUSA
  4. 4.Hawaii Center for AIDSUniversity of HawaiiHonoluluUSA
  5. 5.Department of Laboratory SciencesUSA
  6. 6.Department of School of Public Health and Family MedicineUniversity of Cape TownCape Town
  7. 7.International Centre for AIDS Care and Treatment Programs, Department of Epidemiology, Mailman School of Public HealthColumbia UniversityNew YorkUSA

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