Journal of NeuroVirology

, Volume 16, Issue 3, pp 189–202

NeuroAIDS in Africa

  • Kevin Robertson
  • Jeff Liner
  • James Hakim
  • Jean-Louis Sankalé
  • Igor Grant
  • Scott Letendre
  • David Clifford
  • Amadou Gallo Diop
  • Assan Jaye
  • Georgette Kanmogne
  • Alfred Njamnshi
  • T. Dianne Langford
  • Tufa Gemechu Weyessa
  • Charles Wood
  • Mwanza Banda
  • Mina Hosseinipour
  • Ned Sacktor
  • Noeline Nakasuja
  • Paul Bangirana
  • Robert Paul
  • John Joska
  • Joseph Wong
  • Michael Boivin
  • Penny Holding
  • Betsy Kammerer
  • Annelies Van Rie
  • Prudence Ive
  • Avindra Nath
  • Kathy Lawler
  • Clement Adebamowo
  • Walter Royal
  • Jeymohan Joseph
  • NeuroAIDS in Africa Conference Participants
Review

Abstract

In July 2009, the Center for Mental Health Research on AIDS at the National Institute of Mental Health organized and supported the meeting “NeuroAIDS in Africa.” This meeting was held in Cape Town, South Africa, and was affiliated with the 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Presentations began with an overview of the epidemiology of HIV in sub-Saharan Africa, the molecular epidemiology of HIV, HIV-associated neurocognitive disorders (HANDs), and HAND treatment. These introductory talks were followed by presentations on HAND research and clinical care in Botswana, Cameroon, Ethiopia, The Gambia, Kenya, Malawi, Nigeria, Senegal, South Africa, Uganda, and Zambia. Topics discussed included best practices for assessing neurocognitive disorders, patterns of central nervous system (CNS) involvement in the region, subtype-associated risk for HAND, pediatric HIV assessments and neurodevelopment, HIV-associated CNS opportunistic infections and immune reconstitution syndrome, the evolving changes in treatment implementation, and various opportunities and strategies for NeuroAIDS research and capacity building in the region.

Keywords

HIV neurodevelopment neurology neuropsychology subtypes 

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References

  1. Abubakar A, Holding P, van Baar A, Newton CR, van de Vijver FJ (2008). Monitoring psychomotor development in a resource-limited setting: an evaluation of the Kilifi Developmental Inventory. Ann Trop Paediatr 28: 217–226.CrossRefPubMedGoogle Scholar
  2. Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG, Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M, Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE (2007). Updated research nosology for HIV-associated neurocognitive disorders. Neurology 69: 1789–1799.CrossRefPubMedGoogle Scholar
  3. Clifford DB, Mitike MT, Mekonnen Y, Zhang J, Zenebe G, Melaku Z, Zewde A, Gessesse N, Wolday D, Messele T, Teshome M, Evans S (2007). Neurological evaluation of untreated human immunodeficiency virus infected adults in Ethiopia. J NeuroVirol 13: 67–72.CrossRefPubMedGoogle Scholar
  4. Descamps D, Collin G, Letourneur F, Apetrei C, Damond F, Loussert-Ajaka I, Simon F, Saragosti S, Brun-Vezinet F (1997). Susceptibility of human immunodeficiency virus type 1 group O isolates to antiretroviral agents: in vitro phenotypic and genotypic analyses. J Virol 71: 8893–8898.PubMedGoogle Scholar
  5. Diamond GW, Kaufman J, Belman AL, Cohen L, Cohen HJ, Rubinstein A (1987). Characterization of cognitive functioning in a subgroup of children with congenital HIV infection. Arch Clin Neuropsychol 2: 245–256.PubMedGoogle Scholar
  6. Epstein LG, Sharer LR, Oleske JM, Connor EM, Goudsmit J, Bagdon L, Robert-Guroff M, Koenigsberger MR (1986). Neurologic manifestations of human immunodeficiency virus infection in children. Pediatrics 78: 678–687.PubMedGoogle Scholar
  7. Gupta JD, Satishchandra P, Gopukumar K, Wilkie F, Waldrop-Valverde D, Ellis R, Ownby R, Subbakrishna DK, Desai A, Kamat A, Ravi V, Rao BS, Satish KS, Kumar M (2007). Neuropsychological deficits in human immunodeficiency virus type 1 clade C-seropositive adults from South India. J NeuroVirol 13: 195–202.CrossRefPubMedGoogle Scholar
  8. Hemelaar J, Gouws E, Ghys PD, Osmanov S (2006). Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004. AIDS 20: W13-W23.CrossRefPubMedGoogle Scholar
  9. Hoelscher M, Dowling WE, Sanders-Buell E, Carr JK, Harris ME, Thomschke A, Robb ML, Birx DL, McCutchan FE (2002). Detection of HIV-1 subtypes, recombinants, and dual infections in east Africa by a multi-region hybridization assay. AIDS 16: 2055–2064.CrossRefPubMedGoogle Scholar
  10. Kanki PJ, Hamel DJ, Sankale JL, Hsieh C, Thior I, Barin F, Woodcock SA, Gueye-Ndiaye A, Zhang E, Montano M, Siby T, Marlink R, I ND, Essex ME, S MB (1999). Human immunodeficiency virus type 1 subtypes differ in disease progression. J Infect Dis 179: 68–73.CrossRefPubMedGoogle Scholar
  11. Laeyendecker O, Li X, Arroyo M, McCutchan F, Gray R, Wawer M, Serwadda D, Nalugoda F, Kigozi G, Quinn T, and Rakai Health Science Program (2006). 13th Conference on Retroviruses and Opportunistic Infections; February 5–February 8, 2006; Denver, CO.Google Scholar
  12. LANL (2010). The circulating recombinant forms (CRFs). In: HIV Sequence Database. Los Alamos, NM: Los Alamos National Laboratory.Google Scholar
  13. Miller RF, Isaacson PG, Hall-Craggs M, Lucas S, Gray F, Scaravilli F, An SF (2004). Cerebral CD8+ lymphocytosis in HIV-1 infected patients with immune restoration induced by HAART. Acta Neuropathol 108: 17–23.CrossRefPubMedGoogle Scholar
  14. Newell ML, Coovadia H, Cortina-Borja M, Rollins N, Gaillard P, Dabis F (2004). Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis. Lancet 364: 1236–1243.CrossRefPubMedGoogle Scholar
  15. Poveda E, de Mendoza C, Parkin N, Choe S, Garcia-Gasco P, Corral A, Soriano V (2008). Evidence for different susceptibility to tipranavir and darunavir in patients infected with distinct HIV-1 subtypes. AIDS 22: 611–616.CrossRefPubMedGoogle Scholar
  16. Ren J, Bird LE, Chamberlain PP, Stewart-Jones GB, Stuart DI, Stammers DK (2002). Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors. Proc Natl Acad Sci USA 99: 14410–14415.CrossRefPubMedGoogle Scholar
  17. Riedel DJ, Pardo CA, McArthur J, Nath A (2006). Therapy insight: CNS manifestations of HIV-associated immune reconstitution inflammatory syndrome. Nat Clin Pract Neurol 2: 557–565.CrossRefPubMedGoogle Scholar
  18. Shelburne SA, Montes M, Hamill RJ (2006). Immune reconstitution inflammatory syndrome: more answers, more questions. J Antimicrob Chemother 57: 167–170.CrossRefPubMedGoogle Scholar
  19. Tscherning C, Alaeus A, Fredriksson R, Bjorndal A, Deng H, Littman DR, Fenyo EM, Albert J (1998). Differences in chemokine coreceptor usage between genetic subtypes of HIV-1. Virology 241: 181–188.CrossRefPubMedGoogle Scholar
  20. Van Rie A, Dow A, Mupuala A, Stewart P (2009). Neuro-developmental trajectory of HIV-infected children accessing care in Kinshasa, Democratic Republic of Congo. J Acquir Immune Defic Syndr 52: 636–642.CrossRefPubMedGoogle Scholar
  21. Van Rie A, Mupuala A, Dow A (2008). Impact of the HIV/ AIDS epidemic on the neurodevelopment of preschoolaged children in Kinshasa, Democratic Republic of the Congo. Pediatrics 122: e123-e128.CrossRefPubMedGoogle Scholar
  22. Vasan A, Renjifo B, Hertzmark E, Chaplin B, Msamanga G, Essex M, Fawzi W, Hunter D (2006). Different rates of disease progression of HIV type 1 infection in Tanzania based on infecting subtype. Clin Infect Dis 42: 843–852.CrossRefPubMedGoogle Scholar
  23. Venkataramana A, Pardo CA, McArthur JC, Kerr DA, Irani DN, Griffin JW, Burger P, Reich DS, Calabresi PA, Nath A (2006). Immune reconstitution inflammatory syndrome in the CNS of HIV-infected patients. Neurology 67: 383–388.CrossRefPubMedGoogle Scholar
  24. WHO/UNAIDS (2008). Report on the Global AIDS Epidemic. Epub: http://www.unaids.org/en/KnowledgeCentre/ HIVData/GlobalReport/2008/2008_Global_report.aspGoogle Scholar
  25. Williams PL, Marino M, Malee K, Brogly S, Hughes MD, Mofenson LM (2010). Neurodevelopment and in utero antiretroviral exposure of HIV-exposed uninfected infants. Pediatrics 125: e250-e260.CrossRefPubMedGoogle Scholar

Copyright information

© Journal of NeuroVirology, Inc. 2010

Authors and Affiliations

  • Kevin Robertson
    • 1
  • Jeff Liner
    • 1
  • James Hakim
    • 2
  • Jean-Louis Sankalé
    • 3
  • Igor Grant
    • 4
  • Scott Letendre
    • 4
  • David Clifford
    • 5
  • Amadou Gallo Diop
    • 6
  • Assan Jaye
    • 7
  • Georgette Kanmogne
    • 8
  • Alfred Njamnshi
    • 9
  • T. Dianne Langford
    • 10
  • Tufa Gemechu Weyessa
    • 11
  • Charles Wood
    • 12
  • Mwanza Banda
    • 13
  • Mina Hosseinipour
    • 14
  • Ned Sacktor
    • 15
  • Noeline Nakasuja
    • 16
  • Paul Bangirana
    • 16
  • Robert Paul
    • 17
  • John Joska
    • 18
  • Joseph Wong
    • 19
  • Michael Boivin
    • 20
  • Penny Holding
    • 21
  • Betsy Kammerer
    • 22
  • Annelies Van Rie
    • 23
  • Prudence Ive
    • 24
  • Avindra Nath
    • 25
  • Kathy Lawler
    • 26
  • Clement Adebamowo
    • 27
  • Walter Royal
    • 28
  • Jeymohan Joseph
    • 29
  • NeuroAIDS in Africa Conference Participants
  1. 1.Department of NeurologyUniversity of North CarolinaChapel HillUSA
  2. 2.University of ZimbabweHarareZimbabwe
  3. 3.Globomics, LLCDecaturUSA
  4. 4.University of CaliforniaSan Diego, La JollaUSA
  5. 5.Washington University School of MedicineSt. LouisUSA
  6. 6.University of DakarDakarSenegal
  7. 7.Medical Research Council LaboratoriesGambia UnitBanjulThe Gambia
  8. 8.University of Nebraska Medical CenterOmahaUSA
  9. 9.University of YaoundéYaoundéCameroon
  10. 10.Temple University School of MedicinePhiladelphiaUSA
  11. 11.Addis Ababa UniversityAddis AbabaEthiopia
  12. 12.Nebraska Center for VirologyUniversity of Nebraska-LincolnLincolnUSA
  13. 13.University Teaching HospitalLusakaZambia
  14. 14.UNC ProjectLilongweMalawi
  15. 15.Johns Hopkins Bayview Medical CenterJohns Hopkins UniversityBaltimoreUSA
  16. 16.Makerere UniversityKampalaUganda
  17. 17.University of MissouriSt. Louis, ChesterfieldUSA
  18. 18.University of Cape TownCape TownSouth Africa
  19. 19.University of CaliforniaSan Francisco, San FranciscoUSA
  20. 20.Michigan State UniversityEast LansingUSA
  21. 21.Case Western Reserve UniversityClevelandUSA
  22. 22.Children’s HospitalBoston/Harvard Medical SchoolNewtonUSA
  23. 23.University of North Carolina at Chapel HillChapel HillUSA
  24. 24.Clinical HIV Research UnitHelen Joseph HospitalGautengSouth Africa
  25. 25.Johns Hopkins UniversityBaltimoreUSA
  26. 26.University of PennsylvaniaPhiladelphiaUSA
  27. 27.Office of Strategic Information and ResearchInstitute of Human VirologyAbujaNigeria
  28. 28.University of Maryland School of MedicineBaltimoreUSA
  29. 29.HIV Pathogenesis, Neuropsychiatry and Treatment Branch, Center for Mental Health Research on AIDS, National Institute of Mental HealthNational Institutes of HealthBethesdaUSA

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