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Experimental Study of Albendazole Immunotropic Activity in Low Doses

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Abstract

Evaluation of the immunotropic effect of albendazole in low therapeutic doses has been carried out based on testing the ability of CBA × C57BL/6 mice lines to induce a delayed-type hypersensitivity (DTH) and the synthesis of antibodies against the thymus-dependent antigen. It has been shown that albendazole at doses of 2.5 and 5.0 mg/kg had no effect on the immune response of the cellular and humoral type. The DTH indices were 10.1 ± 3.14 and 10.8 ± 2.45%, respectively, and slightly exceeded those in the control by 3.1 and 10.2%. When albendazole was administered to immunized animals at doses of 2.5 and 5.0 mg/kg, log1/2 of the blood hemagglutinin titer was 6.8 ± 0.46 and 7.0 ± 0.47, and effect indices of albendazole were 1.03 and 1.06. The titer of hemagglutinins in the blood of experimental animals exceeded that in the control by 3.0 and 6.1%, respectively. It has been shown that immunocompetent cells, which functionally provide the formation of delayed-type hypersensitivity and the synthesis of antibodies against the thymus-dependent antigen, are tolerant to albendazole. Albendazole at low therapeutic doses of 2.5 and 5.0 mg/kg with a single administration did not have immunotropic activity. At the tested doses, albendazole is not a regulator of cellular and humoral processes since it does not contribute to modulation of the functional activity of immunocompetent cells and their cooperative interaction, which are necessary for the development of an immune response of the cellular and humoral type.

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Correspondence to O. I. Mamykova.

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Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by A. Ostyak

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Mamykova, O.I. Experimental Study of Albendazole Immunotropic Activity in Low Doses. Russ. Agricult. Sci. 47, 88–92 (2021). https://doi.org/10.3103/S1068367421010122

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