Physiological properties of platelet aggregation in Ayrshire cattle during the first year of life


Surveys were performed with 248 healthy Ayrshire calves, including 74 newborn calves, 65 milkfed calves, and 42 vegetarian-fed calves. During the first year of life, the summation index of platelet aggregations induced by ADP, ristomicine, and collagen gradually increased, reaching 22.40 ± 2.16%, 8.23 ± 0.27%, and 8.14 ± 0.81%, respectively. The most stable aggregations were the aggregations induced by ristomicine. The index of platelet disaggregation induced by ristomicine reached the minimum values (2.21 ± 0.09) at the age of 12 months. The aggregations induced by ADP and collagen were less stable. The indices of platelet disaggregation induced by collagen and ADP tended to increase up to 2.70 ± 0.24% and 12.22 ± 0.76%, respectively. The low level of the platelet hemostatic activity, which is typical for the Ayrshire cattle during the first year of life, ensures both the adaptation of the hemostasis processes to the environmental conditions and the optimal capillary perfusion in the growing and maturing organs.

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  1. 1.

    Glagoleva, T.I., Ontogenetic dynamics of the main hematological indicators in cattle, Vet. Zootekh. Biotekhnol., 2016, no. 5, pp. 6–69.

    Google Scholar 

  2. 2.

    Korepanova, L.V., Starostina, O.S., and Batanov, S.D., Blood as an indicator of the interior features of crossed animals, Zootekhniya, 2015, no. 10, pp. 26–28.

    Google Scholar 

  3. 3.

    Zavalishina, S.Yu. Hemostatic activity of vascular wall of newborn calves, Russ. Agric. Sci., 2012, vol. 38, no. 1, pp. 51–54.

    Article  Google Scholar 

  4. 4.

    Zavalishina, S.Yu. State of coagulation and vascular interactions in newborn calves with iron deficiency after Ferroglucinum intramuscular injection and Glicopin introduction, Russ. Agric. Sci., 2014, vol. 40, no. 2, pp. 143–145.

    Article  Google Scholar 

  5. 5.

    Lazareva, E.N., Mamotrueva, M.A., and Lomakin, N.N., A modern view of the morphofunctional features of platelets, Estestv. Nauki, 2005, no. 3, pp. 36–42.

    Google Scholar 

  6. 6.

    Zavalishina, S.Yu. Activity of vascular hemostasis in milk-fed calves, Russ. Agric. Sci., 2012, vol. 38, no. 4, pp. 321–323.

    Article  Google Scholar 

  7. 7.

    Zavalishina, S.Yu. Hemostatic activity of platelets in calves in the phase of dairy nutrition, Sel’skokhoz. Biol., 2013, no. 4, pp. 105–109.

    Google Scholar 

  8. 8.

    Kutafina, N.V., Thrombocyte mechanisms against the background of growth processes in cattle, Vet. Zootekh. Biotekhnol., 2015, no. 8, pp. 37–42.

    Google Scholar 

  9. 9.

    Medvedev, I.N. and Gromnatskii, N.I., Correction of platelet hemostasis and a decrease in biological age in metabolic syndrome, Klin. Med., 2005, vol. 83, no. 8, pp. 54–57.

    CAS  Google Scholar 

  10. 10.

    Gromnatskii, N.I. and Medvedev, I.N., Correction of platelet hemostasis disorders by non-medicamentous agents in patients with arterial hypertension with metabolic syndrome, Klin. Med., 2003, vol. 81, no. 4, pp. 31–34.

    CAS  Google Scholar 

  11. 11.

    Medvedev, I.N., Lapshina, E.V., and Zavalishina, S.Yu. Activity of platelet hemostasis in children with curvature of the spine, Byull. Eksp. Biol. Med., 2010, vol. 149, no. 5, pp. 579–580.

    Article  Google Scholar 

  12. 12.

    Medvedev, I.N., Dynamics of violations of intravascular activity of platelets in rats during the formation of metabolic syndrome with the help of fructose model, Vopr. Pitan., 2016, vol. 85, no. 1, pp. 42–46.

    CAS  PubMed  Google Scholar 

  13. 13.

    Zavalishina, S.Yu., Kutafna, N.V., Vatnikov, Yu.A., Makurina, O.N., Kulikov, E.V. et al., Platelet-activity dependence on the age of rats with experimental dyslipidemia, Biol. Med. (Aligarh), 2016, vol. 8, no. 6. doi 10.4172/0974-8369.1000326

    Google Scholar 

  14. 14.

    Shitikova, A.S., Trombotsitopatii vrozhdennye i priobretennye (Congenital and Acquired Thrombocytopathy), St. Petersburg: IITs VMA, 2008.

    Google Scholar 

  15. 15.

    Bel'kov, G.I. and Panin, V.A., Milk productivity of hybrids obtained from crossing Simmental cows with bulls of Holstein breed of different populations, Ross. Skh. Nauka, 2015, no. 3, pp. 47–49.

    Google Scholar 

  16. 16.

    Prokhorenko, P.N., Tulinova, O.V., and Vasil’eva, E.N., Condition and prospects of breeding of the Ayrshire breed of cattle, Molochn. Myasn. Skotovod. (Moscow), 2014, no. 5, pp. 6–9.

    Google Scholar 

  17. 17.

    Tyapugin, E., Tyapugin, S., Abramova, N., Vlasova, G., and Bogoradova, L., Formation of the population of the Ayrshire breed of cattle in the Vologda region, Molochn. Myasn. Skotovod. (Moscow), 2011, no. 4, pp. 29–30.

    Google Scholar 

  18. 18.

    Medvedev, I.N., Savchenko, A.P., Zavalishina, S.Yu., Krasnova, E.G., Kumova, T.A., Gamolina, O.V., Skoryakina, I.A., and Fadeeva, T.S., Methodological approaches to the study of the rheological properties of blood in different states, Ross. Kardiol. Zh., 2009, no. 5, pp. 42–45.

    Google Scholar 

  19. 19.

    Amelina, I.V. and Medvedev, I.N., Estimation of the dependence of the level of mutagenesis on the activity of the nucleolus-forming regions of chromosomes among the indigenous population of the Kursk region, Byull. Eksp. Biol. Med., 2008, vol. 145, no. 1, pp. 74–78.

    Article  Google Scholar 

  20. 20.

    Amelina, I.V. and Medvedev, I.N., The manifestation of transcriptional activity of the nucleolus-forming regions of chromosomes in the Kursk region, Byull. Eksp. Biol. Med., 2009, vol. 147, no. 6, pp. 671–673.

    Article  Google Scholar 

  21. 21.

    Erdem, H., Atasever, S., and Kul, E., Some environmental factors affecting somatic cell count of holstein cows, J. Appl. Anim. Res., 2008, vol. 19, no. 3, pp. 195–199.

    Google Scholar 

  22. 22.

    Hernández-Julio, F.Y., Yanagi, Tadayuki, Jr., Pires, M.F.Á., Lopes, M.A. and de Lima, R.R., Models for prediction of physiological responses of Holstein dairy cows, Appl. Artif. Intell., 2014, vol. 28, no. 8, pp. 766–792.

    Article  Google Scholar 

  23. 23.

    Nagy, O., Tóthová, C., and Kovác, G., Age-related changes in the concentrations of serum proteins in calves, J. Appl. Anim. Res., 2014, vol. 42, no. 4, pp. 451–458.

    CAS  Article  Google Scholar 

  24. 24.

    Zavalishina, S.Yu. and Medvedev, I.N., Aggregational features of erythrocytes and platelets in old rats experiencing regular exercise on the treadmill, Usp. Gerontol., 2016, vol. 2, no. 3, pp. 437–441.

    Google Scholar 

  25. 25.

    Medvedev, I.N., Maksimov, V.I., Parakhnevich, A.V., Zavalishina, S.Yu., and Kutafna, N.V., Rapid assessment of aggregation abilities and surface properties of platelets and red blood cells, Int. J. Pharma Bio Sci., 2016, vol. 7, no. 2, pp. 793–797.

    Google Scholar 

  26. 26.

    Smyth, S.S., Mcewer, P.P., Weyrich, A.S. et al., Platelet functions beyond hemostasis, J. Thromb. Haemost., 2009, vol. 7, no. 10, pp. 1759–1765.

    CAS  Article  PubMed  Google Scholar 

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Correspondence to I. N. Medvedev.

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Original Russian Text © I.N. Medvedev, Yu.L. Oshurkova, 2017, published in Rossiiskaya Sel’skokhozyaistvennaya Nauka, 2017, No. 2, pp. 43–47.

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Medvedev, I.N., Oshurkova, Y.L. Physiological properties of platelet aggregation in Ayrshire cattle during the first year of life. Russ. Agricult. Sci. 43, 255–258 (2017).

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  • Ayrshire breed
  • calves
  • early ontogenesis
  • platelet
  • aggregation