We have found that roncoleukine (recombinant interleukin 2, rIL-2) when double administered in the dose of 5000 IU/kg of body weight or 10000 IU/kg of body weight enhanced functional activity of the effector cells of the delayed type hypersensitivity. It was demonstrated that the selective action of rIL-2 in the dose of 10000 IU/kg of body weight induced protective effect (more than 50%) in the mice experimentally infected with T. spiralis.
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Original Russian Text © O.I. Mamykova, 2016, published in Rossiiskaya Sel’skokhozyaistvennaya Nauka, 2016, No. 1, pp. 53–57.
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Mamykova, O.I. Experimental assessment of immunobiological activity of the roncoleukine immunomodulatory agent. Russ. Agricult. Sci. 42, 184–187 (2016). https://doi.org/10.3103/S1068367416020087
- immunomodulating agent
- immunobiological activity
- protective effect
- cell-mediated and humoral immunity