Experimental assessment of immunobiological activity of the roncoleukine immunomodulatory agent


We have found that roncoleukine (recombinant interleukin 2, rIL-2) when double administered in the dose of 5000 IU/kg of body weight or 10000 IU/kg of body weight enhanced functional activity of the effector cells of the delayed type hypersensitivity. It was demonstrated that the selective action of rIL-2 in the dose of 10000 IU/kg of body weight induced protective effect (more than 50%) in the mice experimentally infected with T. spiralis.

This is a preview of subscription content, access via your institution.


  1. 1.

    Mamykova, O.I., Anthelmintic activity of Panacur combinations with immunoactive drugs, Tr. Vseross. Inst. Gel’mintol., 2000, vol. 36, pp. 102–117.

    Google Scholar 

  2. 2.

    Mamykova, O.I., Immunomodulating activity of Tactivin prescribed with fenbendazole in various regimens, Russ. Agric. Sci., 2008, vol. 34, no. 3, pp. 199–202.

    Article  Google Scholar 

  3. 3.

    Kitamura, K., A Footpad weight assay method to evaluate delayed-type hypersensitivity in the mouse, Immunol. Mehtods, 1980, vol. 39, no. 3, pp. 277–283.

    CAS  Google Scholar 

  4. 4.

    Sever, J.L., Application of a microtechnique to viral serological investigations, J. Immunol., 1962, vol. 88, no. 1, pp. 398–413.

    Google Scholar 

  5. 5.

    Chernov, V.A., Metody eksperimental’noi khimioterapii (Methods of Experimental Chemotherapy), Moscow: Meditsina, 1972.

    Google Scholar 

  6. 6.

    Stepanenko, R.N., Thymus-dependent suppressor cells, in Itogi nauki i tekhniki. Ser. Obshchie voprosy patologii (Results of Science and Technology. Ser. General Problems of Pathology), Moscow, 1976, vol. 4, pp. 90–100.

    Google Scholar 

  7. 7.

    Terry, R. and Hudson, K., Immunodepression in parasitic infection, Fortschr. Zool., 1982, vol. 27, pp. 125–139.

    Google Scholar 

  8. 8.

    Cathy, S. and Nutman, Th.B., Helminth antigens selectively differentiate insensitive CD45RA+ CD4+ human T-cells in vivo, J. Immunol., 1998, vol. 16, no. 1, pp. 351–360.

    Google Scholar 

  9. 9.

    Heinzel, F.P., Ahmed, F., and Hujer, A.V., at al., Immunoregulation of murine leishmaniasis by interleukin 12, Res. Immunol., 1995, vol. 146, nos. 7–8, pp. 575–582.

    CAS  Article  PubMed  Google Scholar 

  10. 10.

    Meeusen Els, N.T., Immunology of helminth infection, with special reference to immunophathology, Vet. Parasitol., 1999, vol. 84, pp. 259–273.

    Google Scholar 

  11. 11.

    Fowell, D.J., Wakil, A.T., and Locksley, R.M., Interleukin-12 in murine leishmaniasis match, flame or fuel?, Res. Immunol., 1995, vol. 146, nos. 7–8, pp. 566–571.

    CAS  Article  PubMed  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to O. I. Mamykova.

Additional information

Original Russian Text © O.I. Mamykova, 2016, published in Rossiiskaya Sel’skokhozyaistvennaya Nauka, 2016, No. 1, pp. 53–57.

About this article

Verify currency and authenticity via CrossMark

Cite this article

Mamykova, O.I. Experimental assessment of immunobiological activity of the roncoleukine immunomodulatory agent. Russ. Agricult. Sci. 42, 184–187 (2016). https://doi.org/10.3103/S1068367416020087

Download citation


  • immunomodulating agent
  • immunobiological activity
  • protective effect
  • antibodies
  • cell-mediated and humoral immunity