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X-ray Contrast Properties of Bismuth-Based Nanoformulations

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Abstract

The possibility of using elemental bismuth nanoparticles as sensitizers for radiation therapy and computed tomography contrast agents is investigated. A comparative analysis of the X-ray contrast properties of bismuth nanoparticles with classical gold nanoparticles and bismuth oxychloride nanosheets is carried out. It is shown that laser-synthesized bismuth nanoparticles demonstrate higher X-ray contrast efficiency compared to traditional gold nanoparticles; they also have X-ray contrast properties similar to those of chemically synthesized analogues based on bismuth oxychloride nanosheets. Unique physicochemical characteristics in combination with high radiopaque properties of laser-synthesized bismuth nanoparticles form a new promising alternative to traditional sensitizers for radiation theranostics of oncological diseases.

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Funding

The authors thank the Ministry of Science and Higher Education of the Russian Federation for providing materials for laser synthesis (agreement no. 075-15-2021-1347), as well as for providing infrastructure (grant FSWU-2023–0070).

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Authors and Affiliations

  1. National Research Nuclear University MEPhI, Institute for Physics and Engineering in Biomedicine, 115409, Moscow, Russia

    M. S. Savinov, O. Y. Griaznova, G. V. Tikhonowski, A. A. Popov & S. M. Klimentov

  2. Skolkovo Institute of Science and Technology, Center for Photonic Science and Engineering, 121205, Moscow, Russia

    O. Y. Griaznova

  3. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia

    O. Y. Griaznova

  4. Lebedev Physical Institute, Russian Academy of Sciences, 119991, Moscow, Russia

    I. N. Zavestovskaya

  5. LP3, Aix Marseille University, CNRS, 13288, Marseille, France

    A. V. Kabashin

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  1. M. S. Savinov
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  2. O. Y. Griaznova
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  3. G. V. Tikhonowski
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  4. A. A. Popov
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  6. S. M. Klimentov
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  7. A. V. Kabashin
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Correspondence to M. S. Savinov.

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Translated by V. Derbov

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Savinov, M.S., Griaznova, O.Y., Tikhonowski, G.V. et al. X-ray Contrast Properties of Bismuth-Based Nanoformulations. Bull. Lebedev Phys. Inst. 50 (Suppl 11), S1265–S1271 (2023). https://doi.org/10.3103/S1068335623220141

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  • DOI: https://doi.org/10.3103/S1068335623220141

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