Abstract
The dependence of the efficiency of photothermal conversion of laser-synthesized bismuth (Bi) nanoparticles (NP) on size characteristics for applications in photothermal therapy is studied. It was shown that a decrease in the mode and half-width of the size distribution causes an increase in the photothermal conversion efficiency. Despite a decrease in the extinction in the relative transparency window of biological tissues (650–950 nm), Bi NPs of smaller sizes exhibit a more pronounced photothermal response caused by an increased contribution of absorption to the extinction. The unique combination of physicochemical properties of laser-synthesized Bi NPs forms a new promising alternative to conventional sensitizers of photothermal therapy of oncological diseases.
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Funding
Studies of synthesis and characterization of photothermal properties of NPs were supported by the Ministry of Science and Higher Education of the Russian Federation within the agreement no. 075-15-2021-1347.
The authors also acknowledge the Ministry of Science and Higher Education of the Russian Federation for the infrastructure put at their disposal for studies within project no. FSWU-2023-0070.
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Translated by A. Kazantsev
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Sozaev, I.V., Tikhonowski, G.V., Savinov, M.S. et al. Laser-Synthesized Bismuth Nanoparticles with Controlled Efficiency of Photothermal Conversion for Multimodal Theranostics. Bull. Lebedev Phys. Inst. 50, 498–502 (2023). https://doi.org/10.3103/S106833562311012X
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DOI: https://doi.org/10.3103/S106833562311012X