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Behavior of gallium-68 incorporated in NODA aminoglucose in laboratory animals with various pathological processes

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Abstract

Comparative results of the study of the biological distribution of 68Ga incorporated in NODA aminoglucose in mice organs and tissues with the experimental model of malignant tumor and aseptic inflammation are presented. It is revealed that pathological conditions have no significant effect on the 68Ga-NODA aminoglucose behavior after intravenous administration. The dynamics of activity accumulation and excretion in most organs and tissues had no significant differences. The level of activity accumulation in tumor and muscular tissue with inflammation at 1 h after injection of 68Ga-NODA-aminoglucose exceeded the same values in other organs and tissues, except kidneys. The obtained results show the promising application of 68Ga-NODA- aminoglucose for imaging pathological lesions by positron emission tomography.

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Funding

This study was supported by the Ministry of Science and Higher Education of the Russian Federation (agreement no. 075-02-2018-097, November 26, 2018), project no. RFMEFI57518X0174.

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Authors and Affiliations

  1. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Radiological Center of the Ministry Of Health of the Russian Federation, 249036, Obninsk, Russia

    V. K. Tishchenko, V. M. Petriev, A. V. Fedorova & T. Yu. Ekatova

  2. National Research Nuclear University “MEPhI”, 115409, Moscow, Russia

    V. K. Tishchenko, V. M. Petriev & I. N. Zavestovskaya

  3. Lebedev Physical Institute, Russian Academy of Sciences, 119991, Moscow, Russia

    I. N. Zavestovskaya

Authors
  1. V. K. Tishchenko
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  2. V. M. Petriev
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  3. A. V. Fedorova
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  4. T. Yu. Ekatova
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  5. I. N. Zavestovskaya
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Corresponding authors

Correspondence to V. K. Tishchenko, V. M. Petriev, A. V. Fedorova, T. Yu. Ekatova or I. N. Zavestovskaya.

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Translated by A. Kazantsev

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Tishchenko, V.K., Petriev, V.M., Fedorova, A.V. et al. Behavior of gallium-68 incorporated in NODA aminoglucose in laboratory animals with various pathological processes. Bull. Lebedev Phys. Inst. 47, 213–217 (2020). https://doi.org/10.3103/S1068335620070064

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  • DOI: https://doi.org/10.3103/S1068335620070064

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