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Optical Coherence Microscopy Сombined with Optical Tweezers for Studying Cellular Mechanics

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Abstract—A method combining phase-sensitive optical coherence microscopy (OCM) and optical tweezers for studying mechanical properties of microobjects including biological cells is implemented. The process of microbead trapping was studied using the developed method. The response of the red blood cell (dyscocyte and spherocyte) membrane to the optical tweezer excitation is measured.

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Funding

This study was supported by the Russian Foundation of Basic Research (projects no. 17-08-01716, 18-32-20217, and 18-02-00880), the Russian Science Foundation (project no. 18-72-00247, Experimental setup development), and the Grant of the President of the Russian Federation (project no. MK-2951.2019.2). The study was in part supported by the Center of Quantum Technologies of the Moscow State University and the Ministry of Science and Higher Education (project no. 14.W03.008.31, Simulation of transmission spectra).

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Authors and Affiliations

  1. Moscow State University, 119991, Moscow, Russia

    M. A. Sirotin, M. N. Romodina, E. V. Lyubin, I. V. Soboleva & A. A. Fedyanin

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  1. M. A. Sirotin
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  2. M. N. Romodina
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  3. E. V. Lyubin
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  4. I. V. Soboleva
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  5. A. A. Fedyanin
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Correspondence to M. A. Sirotin.

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Translated by A. Kazantsev

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Sirotin, M.A., Romodina, M.N., Lyubin, E.V. et al. Optical Coherence Microscopy Сombined with Optical Tweezers for Studying Cellular Mechanics. Bull. Lebedev Phys. Inst. 47, 136–139 (2020). https://doi.org/10.3103/S1068335620050073

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  • DOI: https://doi.org/10.3103/S1068335620050073

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