Russian Journal of Non-Ferrous Metals

, Volume 59, Issue 1, pp 111–116 | Cite as

Fabrication of Cerium Oxide Nanoparticles by Solution Combustion Synthesis and Their Cytotoxicity Evaluation

  • M. Zarezadeh Mehrizi
  • S. Ahmadi
  • R. Beygi
  • M. Asadi
Self-Propagating High-Temperature Synthesis


The diverse abilities such as the antioxidant effect of cerium oxide nanoparticles (CeO2-NPs) have encouraged researchers to pursue CeO2-NPs as a therapeutic agent to treat a number of diseases, including cancer and diabetes. The synthesis method of CeO2-NPs affected on its abilities. In this study, nanosize ceria powders were synthesized by combustion of aqueous containing corresponding cerium nitrate, ammonium nitrate, and glycine redox mixtures. Solution combustion synthesis is a fast and cost-efficient process with high purity product. The crystallite structures were characterized by various methods, including X-ray diffraction technique, high-resolution scanning electron microscopy, transmission electron microscopy, and UV–vis spectroscopy technique. The combustion was flaming and yields voluminous oxides with nano size (20–30 nm). In addition, no diffraction patterns that are characteristic of impurities were observed, indicating the purity of the CeO2-NPs. In vitro cytotoxicity studies on L929 cells, a non-toxic effect in all concentration (up to 1000 μg/mL) was indicated and it can be believed that this nanoparticle will have viable applications in different medical fields.


CeO2 nanoparticle solution combustion synthesis cytotoxicity 


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Copyright information

© Allerton Press, Inc. 2018

Authors and Affiliations

  • M. Zarezadeh Mehrizi
    • 1
  • S. Ahmadi
    • 1
  • R. Beygi
    • 1
  • M. Asadi
    • 2
  1. 1.Department of Materials Science and Engineering, Faculty of EngineeringArak UniversityArakIran
  2. 2.Endocrinology and Metabolism Research CenterArak University of Medical SciencesArakIran

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