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Studying the Accumulation of Gadolinium in Human Brain Glioma for Gadolinium-Neutron Capture Therapy

  • Published:
Bulletin of the Russian Academy of Sciences: Physics Aims and scope

Abstract

The accumulation of gadolinium in human brain gliomas is estimated after a single intravenous administration of Magnevist. The study is conducted using samples excised during standard surgeries on human brain gliomas. Gadolinium is present in all five examined samples at concentrations of 0.0093 to 0.2384 ng mg–1 (ppm) of tumor tissue.

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Funding

This work was performed as part of projects FA-Ateh-2018-168 “Developing a Way of Independently Estimating the Radioresistance of Human Brain Gliomas for Clinical Neurooncology” and OT-F2-24 “Studying Characteristics of Secondary Particles That Appear during Interaction between Photons and the Elements Sm, Gd, Au, and Bi” of the Republic of Uzbekistan.

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Authors and Affiliations

  1. Institute of Nuclear Physics, Academy of Sciences of the Republic of Uzbekistan, 100214, Tashkent, Uzbekistan

    G. A. Kulabdullaev, A. A. Kim, G. A. Abdullaeva, G. T. Djuraeva, I. I. Sadikov, B. Kh. Yarmatov & M. I. Salimov

  2. Republic Scientific Center of Neurosurgery, 100201, Tashkent, Uzbekistan

    R. T. Kadirbekov & N. R. Kadirbekov

  3. Tashkent Medical Academy, 100109, Tashkent, Uzbekistan

    I. R. Mavlyanov

Authors
  1. G. A. Kulabdullaev
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  2. A. A. Kim
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  3. G. A. Abdullaeva
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  4. G. T. Djuraeva
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  5. I. I. Sadikov
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  6. B. Kh. Yarmatov
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  7. M. I. Salimov
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  8. R. T. Kadirbekov
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  9. N. R. Kadirbekov
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  10. I. R. Mavlyanov
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Corresponding author

Correspondence to G. A. Kulabdullaev.

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The authors declare that they have no conflicts of interest.

Additional information

Translated by A. Khaitin

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Kulabdullaev, G.A., Kim, A.A., Abdullaeva, G.A. et al. Studying the Accumulation of Gadolinium in Human Brain Glioma for Gadolinium-Neutron Capture Therapy. Bull. Russ. Acad. Sci. Phys. 85, 1445–1450 (2021). https://doi.org/10.3103/S1062873821120182

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  • DOI: https://doi.org/10.3103/S1062873821120182

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