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Using SEM to design a new generation of drug forms

  • Proceedings of the XVIII Russian Symposium on Scanning Electron Microscopy and Analytical Methods of Investigation Used in Solid-State Physics SEM-2013
  • Published:
Bulletin of the Russian Academy of Sciences: Physics Aims and scope

Abstract

Detailed study and understanding of the processes that occur during the cooling and subsequent annealing of frozen solutions of drugs in two-component systems of low boiling point liquids and water with clathrate formation requires the active involvement of scanning electron microscopy (SEM) to select the optimum conditions for freeze drying and comparative analysis of samples, forms of dosage, and initial substances. A new way of creating ultrafine forms of drugs and pharmaceutical compositions by freeze drying that can easily be extended to almost all modern low-dosage drugs to improve their pharmacokinetic profile and technological properties is developed.

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Authors and Affiliations

  1. Center for Molecular Design and Environmentally Friendly Technologies, Novosibirsk State University, Novosibirsk, 630090, Russia

    A. A. Ogienko, S. A. Myz, E. V. Boldyreva, E. G. Zevak, A. G. Ogienko, A. Yu. Manakov & A. I. Ancharov

  2. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia

    A. A. Ogienko

  3. Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630128, Russia

    S. A. Myz, E. V. Boldyreva & A. I. Ancharov

  4. Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia

    E. G. Zevak, A. G. Ogienko, A. Yu. Manakov & B. M. Kuchumov

  5. Central Siberian Botanical Garden, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia

    A. A. Krasnikov

Authors
  1. A. A. Ogienko
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  2. S. A. Myz
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  3. E. V. Boldyreva
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  4. E. G. Zevak
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  5. A. G. Ogienko
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  6. A. Yu. Manakov
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  7. A. I. Ancharov
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  8. B. M. Kuchumov
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  9. A. A. Krasnikov
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Corresponding author

Correspondence to A. G. Ogienko.

Additional information

Original Russian Text © A.A. Ogienko, S.A. Myz, E.V. Boldyreva, E.G. Zevak, A.G. Ogienko, A.Yu. Manakov, A.I. Ancharov, B.M. Kuchumov, A.A. Krasnikov, 2014, published in Izvestiya Rossiiskoi Akademii Nauk. Seriya Fizicheskaya, 2014, Vol. 78, No. 9, pp. 1107–1113.

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Ogienko, A.A., Myz, S.A., Boldyreva, E.V. et al. Using SEM to design a new generation of drug forms. Bull. Russ. Acad. Sci. Phys. 78, 868–873 (2014). https://doi.org/10.3103/S1062873814090202

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  • DOI: https://doi.org/10.3103/S1062873814090202

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