Abstract
In many human populations, from 16 to 60% of individuals are homozygotes for glutathione-S-transferase M1 gene deletion. In this study, we determined the correlation between GSTM1 gene deletion and the genetic diversity of the GSTM cluster (which includes this gene) in three Russian populations. The study was based on the comparison of frequencies of haplotype (composed of single nucleotide polymorphisms) in three Russian populations, where two subgroups of individuals were isolated according to the presence of deletion. The GSTM1 gene was absent in the first subgroup; at least one functional variant of it was found in the second subgroup. Analysis of haplotype frequencies in isolated subgroups did not reveal the specificity in their distribution neither inside the studied populations nor between them.
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Original Russian Text © I.N. Filippova, A.V. Khrunin, S.A. Limborska, 2014, published in Molekulyarnaya Genetika, Mikrobiologiya i Virusologiya, 2014, No. 2, pp. 8–12.
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Filippova, I.N., Khrunin, A.V. & Limborska, S.A. Analysis of GSTM1 gene deletion in the context of the haplotype diversity of the GSTM genomic cluster in three Russian populations. Mol. Genet. Microbiol. Virol. 29, 53–57 (2014). https://doi.org/10.3103/S0891416814020062
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DOI: https://doi.org/10.3103/S0891416814020062