Abstract
Tumor-necrosis factor (TNF) is an inflammatory cytokine that is involved in pathogenesis of different malignancies. The single-nucleotide polymorphism −238(G/A)TNF (rs361525) has been investigated for detection of a predisposition to infectious, autoimmune, and oncological diseases. The goal of the study was to investigate the association of -238(G/A)TNF polymorphism (rs361525) with breast cancer (BC) prognosis. TNF allelic variants were detected by restriction fragment length polymorphism polymerase chain reaction (RFLP-PCR). We did not reveal genotype-distribution disparities among groups with various stages of the disease and various levels of expression of estrogen, progesterone, and epidermal growth factor receptors. The AG genotype frequency was about 10%, and there were no BC patients with the AA genotype in all groups. However, the 5-year survival was significantly lower for AG than GG carriers with stage II or ER-positive BC. Our data suggest that −238(G/A)TNF polymorphism is not involved in the initiation of malignancies but is a substantial factor of BC prognosis.
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Original Russian Text © T.F. Malivanova, E.V. Skoromyslova, V.A. Yurchenko, I.B. Kononenko, L.V. Manzyuk, N.N. Mazurenko, 2013, published in Molekulyarnaya Genetika, Mikrobiologiya i Virusologiya, 2013, No. 2, pp. 13–16.
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Malivanova, T.F., Skoromyslova, E.V., Yurchenko, V.A. et al. Analysis of the −238(G/A)TNF polymorphism in breast-cancer patients. Mol. Genet. Microbiol. Virol. 28, 52–55 (2013). https://doi.org/10.3103/S0891416813020031
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DOI: https://doi.org/10.3103/S0891416813020031