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Components of the Francisella tularensis protective antigen complex

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Abstract

The study presents the structural characteristics of the Francisella tularensis protective antigen complex (PAC)—a water-soluble antigen of the outer membrane (OMs) of the tularemia microorganism with a complex chemical nature with molecular mass of about 280 kDa. The immunochemically active subunits of the antigen protective complex with molecular masses from 81 to 19 kDa are established as having a protein nature, and those with 14–17 kDa are of lipoprotein nature. Stress chaperones (GroES and GroEL), the OM proteins (FRL_0617 and OmpH), regulatory proteins (EF-Tu and RplL), and bacterial enzymes (KatG and GAPDH) and a lipopolysaccharide were indentified in the PAC, which are responsible for its high immunobiological activity.

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Authors and Affiliations

  1. Microbe Russian Antiplague Research Institute, Saratov, Russia

    E. M. Kuznetsova, O. A. Volokh, I. A. Shepelev & A. K. Nikiforov

Authors
  1. E. M. Kuznetsova
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  2. O. A. Volokh
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  3. I. A. Shepelev
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  4. A. K. Nikiforov
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Corresponding author

Correspondence to E. M. Kuznetsova.

Additional information

Original Russian Text © E.M. Kuznetsova, O.A. Volokh, I.A. Shepelev, A.K. Nikiforov, 2012, published in Molekulyarnaya Genetika, Mikrobiologiya i Virusologiya, 2012, no. 3, pp. 22–25.

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Kuznetsova, E.M., Volokh, O.A., Shepelev, I.A. et al. Components of the Francisella tularensis protective antigen complex. Mol. Genet. Microbiol. Virol. 27, 112–116 (2012). https://doi.org/10.3103/S0891416812030044

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  • DOI: https://doi.org/10.3103/S0891416812030044

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